Results 31 to 40 of about 24,207 (226)

Association of a functional IRF7 variant with systemic lupus erythematosus [PDF]

Arthritis & Rheumatism, 2011
A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE).
Wong, JLH, Fu, Q, Zhao, J, Qian, X, Kaufman, KM, Yu, CY, Howe, HS, Mok, MY, Harley, JB, Guthridge, JM, Song, YW, Cho, SK, Bae, SC, Grossman, JM, Hahn, BH, Arnett, FC, Shen, N, Tsao, BP   +17 more
openaire   +5 more sources

Burning down the house: IRF7 makes the difference for microglia [PDF]

The EMBO Journal, 2014
The endogenous microenvironment of the brain is an essential watchdog to guard over myeloid cell function during diseases. Limiting inflammatory reactions of activated microglia and blood-derived monocytes is a key prerequisite for the resolution of tissue insults.
Hagemeyer, Nora, Prinz, Marco
openaire   +3 more sources

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source

The interaction between IRF7 and Ubc12.

, 2021
IB analysis of the interaction between endogenous IRF7 and endogenous Ubc12 in SeV-infected Raw264.7 after IP with an anti-IRF7 antibody (Left) or an anti-Ubc12 antibody (Right).
Chunmei Hou (291664), Qingyang Wang (460264), Qianqian Cheng (4872292), Tao Zou (662198), Xiqin Yang (4623160), Jia He (89641), Chunxiao Niu (11419937), Zhenjie Ye (11419940), Jie Dong (12143), Xiaoyao Feng (11419928), Daohai Cheng (11419934), Min Zhao (66793), Zhuo Shen (9136182), Cheng Qin (703381), Lin Wei (70005), Xueying Zhang (460267), Lijiao Deng (11419931), Yaolin Zhang (6000809), Jiyan Zhang (460271), Jiayang Jin (11419925), Ge Li (65539), Gencheng Han (291658), Xueting Zhang (8160114)   +22 more
core   +1 more source

IRF7 in the Australian black flying fox, Pteropus alecto: evidence for a unique expression pattern and functional conservation. [PDF]

PLoS ONE, 2014
As the only flying mammal, bats harbor a number of emerging and re-emerging viruses, many of which cause severe diseases in humans and other mammals yet result in no clinical symptoms in bats.
Peng Zhou, Chris Cowled, Ashley Mansell, Paul Monaghan, Diane Green, Lijun Wu, Zhengli Shi, Lin-Fa Wang, Michelle L Baker   +8 more
doaj   +1 more source

TRAF6 and IRF7 Control HIV Replication in Macrophages

PLoS ONE, 2011
The innate immune system recognizes virus infection and evokes antiviral responses which include producing type I interferons (IFNs). The induction of IFN provides a crucial mechanism of antiviral defense by upregulating interferon-stimulated genes (ISGs) that restrict viral replication.
Sirois, M., Robitaille, L., Allary, R., Shah, M., Woelk, C.H., Estaquier, J., Corbeil, J.C.   +6 more
openaire   +6 more sources

Mammalia IRF7 is a neddylation substrate.

, 2021
(A, B) HEK-293T cells were transfected with the indicated mammalian expression vectors. Twenty-four hours later, possible neddylation of exogenous mammalian IRF proteins was examined by IB analysis with the indicated antibodies after histidine pulldown ...
Chunmei Hou (291664), Qingyang Wang (460264), Qianqian Cheng (4872292), Tao Zou (662198), Xiqin Yang (4623160), Jia He (89641), Chunxiao Niu (11419937), Zhenjie Ye (11419940), Jie Dong (12143), Xiaoyao Feng (11419928), Daohai Cheng (11419934), Min Zhao (66793), Zhuo Shen (9136182), Cheng Qin (703381), Lin Wei (70005), Xueying Zhang (460267), Lijiao Deng (11419931), Yaolin Zhang (6000809), Jiyan Zhang (460271), Jiayang Jin (11419925), Ge Li (65539), Gencheng Han (291658), Xueting Zhang (8160114)   +22 more
core   +1 more source

Identification of PP1 as the First Phosphatase for IRF7

Journal of Cell Signaling, 2017
Excerpt: Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I ...
Ning, Shunbin, Wang, Ling
openaire   +2 more sources

Negative Regulation of IKKε-Mediated IRF7 Phosphorylation by HSP70 [PDF]

The Journal of Immunology, 2020
Abstract Immune reactions are controlled by the delicate spatiotemporal orchestration of multiple cells communicating by cytokines. Studies of cytokines that began with the discovery of IFN focused on positive regulatory mechanisms that induce secretion in response to harmful stimuli.
Kyoung Jin Lee, Heuiran Lee, Chul Hyun Joo   +2 more
openaire   +2 more sources

Human IRF7 gene variants in health and disease

, 2022
Lupus is a complex heterogeneous disease driven by a combination of genetic and environmental factors. Type 1 interferon (T1 IFN) is central to lupus pathogenesis, with 50-75% of adult lupus patients expressing elevated levels of T1 IFN mRNA in blood ...
Stanley, Maurice
core   +1 more source