Results 21 to 30 of about 24,207 (226)

Targeting IRF7 to overcome gemcitabine resistance in pancreatic ductal adenocarcinoma

iScience
Summary: Interferon regulatory factor 7 (IRF7), a central transcription factor in interferon signaling, contributes to gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). We investigated how IRF7 mediates this resistance and explored
Gang-Hua Yang, Hao-Qi Yan, Zheng-Yang Lu, Qin-Hong Xu, Zheng Wang, Shuo Zhao   +5 more
doaj   +4 more sources

The A20 Deubiquitinase Activity Negatively Regulates LMP1 Activation of IRF7 [PDF]

Journal of Virology, 2010
ABSTRACT A20 possesses both deubiquitinase (DUB) and ubiquitin E3 ligase activities that are required for termination of Toll-like receptor (TLR) signaling leading to NF-κB activation and for blockage of tumor necrosis factor (TNF)-induced cytotoxicity and apoptosis. A20 is induced by the Epstein-Barr virus (EBV) oncoprotein LMP1.
Shunbin, Ning, Joseph S, Pagano
openaire   +4 more sources

Microglial IRF7-induced lipophagy impairment aggravates lipid droplet overload and impedes neurological recovery after ischemic stroke [PDF]

Journal of Neuroinflammation
Lipid droplet (LD) accumulation in microglia results in a dysfunctional and proinflammatory state after ischemic stroke and worsens neurological outcomes; yet how this accumulation is regulated remains unclear. Interferon regulatory factor 7 (IRF7) is an
Jing Yin, Yan Li, Yu-Lu Miao, Xue-Fang Song, Yao Cheng, Yu-Jie Zhai, Jia Ren, Cai-Hong Yang, Hui-Feng Zhang, Xiang-Nan Zhang, Li-Jun Yang, Yan-Ying Fan   +11 more
doaj   +2 more sources

IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis [PDF]

EMBO Molecular Medicine
In response to various stimuli, quiescent resident cardiac fibroblasts undergo metabolic, morphological, and functional alterations, transitioning into myofibroblasts that mediate cardiac fibrosis.
Ming Kong, Chenghao Zhu, Yujia Xue, Wenxuan Hong, Guoqing Zhang, Dingsheng Jiang, Yong Xu, Junli Guo   +7 more
doaj   +2 more sources

Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7 [PDF]

The Journal of Immunology, 2019
Abstract Viral infection activates the transcription factor IFN regulatory factor 7 (IRF7), which plays a critical role in the induction of IFNs and innate antiviral immune response. How virus-induced IFN signaling is controlled in fish is not fully understood. In this study, we demonstrate that N-myc downstream-regulated gene 1a (NDRG1a)
Long-Feng Lu, Shun Li, Zhao-Xi Wang, Shu-Bo Liu, Dan-Dan Chen, Yong-An Zhang   +5 more
core   +4 more sources

TRIM25 promotes antiviral innate immune response by stabilizing IRF7 and its nuclear translocation [PDF]

mBio
Most avian species lack interferon regulatory factor 3 (IRF3), a key transcription factor that initiates antiviral interferon responses, leaving how they achieve rapid RNA virus defense unclear.
Zhen Wu, Yingxuan Cui, Yu He, Tao Wang, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Anchun Cheng, Shun Chen   +18 more
doaj   +2 more sources

Identification of the mitochondria-related gene IRF7 shared by physical exercise and Parkinson’s disease and exploration of its potential molecular mechanisms [PDF]

PeerJ
Background Physical exercise (PE) holds significant clinical value in alleviating the progression of Parkinson’s disease (PD), yet its underlying regulatory mechanisms remain unclear.
Xinyi Hu, Zhiliang Cai, Feiran Zhou, Siliang Chen, Ping Li, Siyi Jin, Songyao Lan, Xiaoyan Du, Rui Xing   +8 more
doaj   +3 more sources

The RASSF1C-HIF-1α axis drives macrophage lipid metabolism to promote pancreatic cancer [PDF]

Cell Death and Disease
Pancreatic adenocarcinoma (PAAD) has a poor prognosis. Its microenvironment is closely associated with tumor progression and immune evasion. This study combines single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to reveal the ...
Ting Zhan, Min Huang, Mengge Chen, Wei Chen, Yiyun Wang, Xiaoli Chen, Yanli Zou, Meng Liu, Qingxi Zhu, Xia Tian, Zheng Han, Xiaodong Huang   +11 more
doaj   +2 more sources

Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency

Frontiers in Immunology
BackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu, Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Edurne Garcia-Vidal, Eudald Felip, Eudald Felip, Eudald Felip, Sara Cabrero-de las Heras, Sara Cabrero-de las Heras, Bonaventura Clotet, Bonaventura Clotet, Roger Badia, Roger Badia, Ester Ballana, Ester Ballana, Ester Ballana, Eva Riveira-Muñoz, Eva Riveira-Muñoz, Maria Nevot, Maria Nevot   +19 more
doaj   +4 more sources

HTLV-1 subverts the innate immune effector gene IRF7 by viral HBZ protein for oncogenesis [PDF]

Nature Communications
Interferon regulatory factors (IRFs) are innate immune transcription factors responsible for inducing the expression of type I interferons (IFN-I), which combat pathogen invasions via initiating the downstream Janus kinase signal transducer and activator
Xiaoyi Yuan, Yunyun Yue, Liang Chen, Dongmei Liu, Yi Liang, Chengcheng Lu, Sikai Yang, Zeng He, Chunxin Fan, Jing Shang, Masao Matsuoka, Guangyong Ma   +11 more
doaj   +2 more sources