Results 11 to 20 of about 24,207 (226)

Opposing roles of deubiquitinases in the regulation of IRF7 transcriptional activity [PDF]

mBio
Virus infection rapidly induces the production and secretion of interferons (IFNs), which amplify the antiviral responses in infected and neighboring uninfected cells.
Shumin Fan, Pracheta Sengupta, Karan Chawla, Manoj Veleeparambil, Ritu Chakravarti, Saurabh Chattopadhyay   +5 more
doaj   +5 more sources

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractObjectiveTo elucidate the role of interferon regulatory factor (IRF)3 and IRF7 in neovascularization.MethodsUnilateral hind limb ischaemia was induced in Irf3−/−, Irf7−/− and C57BL/6 mice by ligation of the left common femoral artery. Post‐ischaemic blood flow recovery in the paw was measured with laser Doppler perfusion imaging.
Simons, K.H., Vries, M.R. de, Jong, R.C.M. de, Peters, H.A.B., Jukema, J.W., Quax, P.H.A.   +5 more
openaire   +4 more sources

Macrophage interferon regulatory factor 7 aggravates the progression of metabolic dysfunction-associated steatohepatitis [PDF]

Molecular Biomedicine
Metabolic dysfunction-associated steatohepatitis (MASH) represents a growing clinical burden with increasing prevalence and lacking approved pharmacological therapies.
Xuhao Ni, Qingfa Bu, Yuan Liang, Bozhou Pan, Jian Wang, Qingxiang Xu, Lei Liu, Qi Wang   +7 more
doaj   +2 more sources

IRF7 is a Prognostic Biomarker and Associated with Immune Infiltration in Stomach Adenocarcinoma

International Journal of General Medicine, 2021
Lili Guo,1 Te Fang,1 Yanhua Jiang,1 Dingsheng Liu2 1Department of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China; 2Department of General Surgery, Shengjing Hospital of China ...
Guo L, Fang T, Jiang Y, Liu D
doaj   +4 more sources

H1N1 Influenza A Virus Protein NS2 Inhibits Innate Immune Response by Targeting IRF7

Viruses, 2022
Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals.
Bo Zhang, Minxuan Liu, Jiaxin Huang, Qiaoying Zeng, Qiyun Zhu, Shuai Xu, Hualan Chen   +6 more
doaj   +2 more sources

IRF7 deficiency in myeloid cells results in increased disease severity and death during alphavirus encephalomyelitis despite intact expression of type I interferons [PDF]

Journal of Neuroinflammation
Alphaviruses are arthropod-borne pathogens that cause immune-mediated encephalomyelitis. The prototypic alphavirus, Sindbis virus (SINV), primarily infects neurons in mice, resulting in neurologic disease involving both the brain and spinal cord ...
Benjamin H. Nguyen, Elise Stanley, Wanmin Dai, Elizabeth M. Troisi, Diane E. Griffin   +4 more
doaj   +2 more sources

Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection

Journal of Neuroinflammation, 2023
Background Type I interferons (IFN-I) are fundamental in controlling viral infections but fatal interferonopathy is restricted in the immune-privileged central nervous system (CNS). In contrast to the well-established role of Interferon Regulatory Factor
Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay, Andrea Kröger   +11 more
doaj   +2 more sources

Pigeon employs a conserved IRF7 gene to mediate innate immune response [PDF]

Poultry Science
Compared with chickens and ducks, pigeons exhibit higher resistance to RNA virus infection. Interferon regulatory factor 7 (IRF7) was identified a member of the interferon regulatory factors (IRFs) family, which plays an important role in innate immune ...
Qi Shao, Qiuju Liu, Jie Wang, Shuhan Li, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Yuqiang Cheng, Jianhe Sun   +9 more
doaj   +2 more sources

IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells.

PLoS ONE, 2012
Members of the Interferon Regulatory Factor (IRF) family of transcription factors play an essential role in the development and function of the immune system.
Benjamin M J Owens, John W J Moore, Paul M Kaye   +2 more
doaj   +2 more sources

IRF7 Protects Against Severe Influenza A Infection Independently of TLR7 Recognition in Mice [PDF]

Viruses
Influenza A virus (IAV) remains a major cause of respiratory morbidity and mortality worldwide. However, the precise role of the RNA sensor Toll-like receptor 7 (TLR7) and its downstream signaling mediator, interferon regulatory factor 7 (IRF7), during ...
Ana Karina Nisperuza Vidal, Chenxiao Wang, Michaela J. Allen, Xiaofeng Ding, Jefferson Fernandes Evangelista, Yilin Chen, Mst Shamima Khatun, Micaela R. Boxer Wachler, Calder R. Ellsworth, Mohammad Islamuddin, Robert Blair, Jay K. Kolls, Derek A. Pociask, Xuebin Qin   +13 more
doaj   +2 more sources