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Interferon regulatory factor 5 polymorphisms in sarcoidosis
Modern Rheumatology, 2013Interferon regulatory factor 5 (IRF5) gene polymorphisms are associated with susceptibility to autoimmune diseases. The aim of this study is to determine the roles of IRF5 single-nucleotide polymorphisms (SNPs) in sarcoidosis.A total of 175 Japanese patients with biopsy-proven sarcoidosis and 150 sex-matched controls were genotyped for four IRF5 SNPs ...
Kiminobu, Tanizawa +12 more
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Interferon Regulatory Factor Signalings in Cardiometabolic Diseases
Hypertension, 2015Cardiometabolic diseases comprise a spectrum of interconnected pathological alterations in metabolic organs and in the cardiovascular system that occur alone or simultaneously.1 Although great efforts have been undertaken to develop therapeutic agents (eg, statins and tissue-type plasminogen activator) for these unfavorable conditions, epidemiological ...
Xiao-Jing, Zhang +2 more
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Interferon regulatory factors: A key to tumour immunity
International Immunopharmacology, 2017Interferon regulatory factors (IRFs), which have 10 members, belong to the transcription factor family and were named because of the regulation of interferon expression. They play important roles in the immune regulation, cell differentiation, cell apoptosis, and cell cycle regulation.
Yan-Jie, Chen +3 more
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Interferon-Independent Protection by Interferon Regulatory Factor 3
The Journal of Immunology, 2018Abstract BACKGROUND Independent type I/III IFN regulation, interferon-regulatory factor 3 (IRF3) can mediate cell death and suppress proliferation during stress. Novel ‘suicide necrosis’ centers around IRF3 and is one protective mechanism against intracellular pathogens.
Clare Elise Gyorke, Uma Nagarajan
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Stimulation of interferon regulatory factor-1 by prolactin
Lupus, 2001Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse cellular functions including proliferation, differentiation, angiogenesis and protection against apoptosis and inflammation. To understand the mechanism of PRL signaling in T cells, we have cloned both PRL and its receptor (PRL-R), one potent mediator of PRL signaling, Stat5b ...
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Transcriptional control of metabolism by interferon regulatory factors
Nature Reviews EndocrinologyInterferon regulatory factors (IRFs) comprise a family of nine transcription factors in mammals. IRFs exert broad effects on almost all aspects of immunity but are best known for their role in the antiviral response. Over the past two decades, IRFs have been implicated in metabolic physiology and pathophysiology, partly as a result of their known ...
Zunair Ahmad +2 more
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The Role of Interferon in Cancer Therapy: A Current Perspective
Ca-A Cancer Journal for Clinicians, 1988David S Goldstein +2 more
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Interferon regulatory factor-1 myelodysplasia and leukemia
Leukemia Research, 2006Dan A, Liebermann, Barbara, Hoffman
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