Results 111 to 120 of about 9,208,925 (289)

Evaluation of Serum Interferon Regulatory Factors (IRF-1, IRF-2, and IRF-4) in Patients with Tularemia

Cumhuriyet Science Journal
Tularemia caused byFrancisella tularensis, is characterized by a complex interplay between the pathogen and the host’s innate immune system. This study aimed to evaluate the diagnostic potential of serum interferon regulatory factors (IRFs) and their ...
Serkan Bolat, Yasemin Çakır Kıymaz, Murtaza Öz, Ertuğrul Keskin   +3 more
doaj   +1 more source

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

, 2006
SummaryInduction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5.
Taniguchi, Tadatsugu, Takaoka, Akinori, Honda, Kenya   +2 more
core   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Innate Antiviral Response: Role in HIV-1 Infection

Viruses, 2011
As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early ...
Paula M. Pitha
doaj   +1 more source

CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks [PDF]

, 2006
Baumbach J, Brinkrolf K, Czaja LF, Rahmann S, Tauch A. CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. BMC Genomics.
Baumbach Jan, Tauch Andreas, Brinkrolf, Karina, Tauch, Andreas, Brinkrolf Karina, Rahmann Sven, Czaja, Lisa F., Baumbach, Jan, Czaja Lisa F, Rahmann, Sven, Sven Rahmann, Andreas Tauch, LisaF Czaja, Jan Baumbach, Karina Brinkrolf   +14 more
core   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?

Frontiers in Immunology, 2018
The interferon regulatory factors (IRFs) are a family of master transcription factors that regulate pathogen-induced innate and acquired immune responses.
Cherrie D. Thompson, Bharati Matta, Betsy J. Barnes   +2 more
doaj   +1 more source

Interferon regulatory factor 6 determines intestinal epithelial cell development and immunity [PDF]

Interferon regulatory factor 6 plays a significant role in the regulation of intestinal epithelial cell identity, interferon response, and ...
Nice, Timothy J., Wright, Austin
core   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source