Interferon Regulatory Factor 9 Structure and Regulation [PDF]
Frontiers in Immunology, 2018 Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has
Alvin Paul, Thean Hock Tang, Siew Kit Ng
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease [PDF]
Neural Regeneration ResearchInterferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou +10 more
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Interferon regulatory factor 1 enhances T cell differentiation in patients with myasthenia gravis [PDF]
Neural Regeneration ResearchInterferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis. However, its function in myasthenia gravis remains unclear.
Yuebei Luo +5 more
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Interferon regulatory factor 4–releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization [PDF]
Neural Regeneration ResearchThree-dimensional (3D)-printed hydrogel scaffolds are widely used in spinal cord injury repair, with gelatin methacrylate being particularly favored owing to its excellent biocompatibility.
Jianhao Wang +7 more
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Low‐grade follicular lymphoma with interferon regulatory factor‐4 rearrangement: Expanding the spectrum of interferon regulatory factor‐4‐rearranged lymphomas [PDF]
eJHaemIn recent years, the recognition of distinct lymphoma entities has expanded with advancements in molecular characterization. Large B‐cell Lymphoma with interferon regulatory factor‐4 (IRF4) rearrangement (LBCL‐IRF4‐R) is one such entity.
Ali Sakhdari +4 more
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Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells [PDF]
Journal of VirologyAbundance of essential components of double-stranded RNA (dsRNA) recognition and the subsequent interferon (IFN) response vary widely between primary human hepatocytes (PHHs) and commonly used cell culture models based on derivatives of Huh7 cells ...
Andreas Betz +13 more
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Frequency-selective thymic programming by early-life cold stress requires interferon regulatory factor 5 [PDF]
Frontiers in ImmunologyBackgroundEarly-life environmental stressors can program immune development, but how the frequency of cold stress shapes thymic programming remains unknown.MethodsDevelopmentally matched (day 4, poikilothermic, yolk sac or milk dependent) zebrafish ...
Shengnan Wang +5 more
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Macrophage interferon regulatory factor 7 aggravates the progression of metabolic dysfunction-associated steatohepatitis [PDF]
Molecular BiomedicineMetabolic dysfunction-associated steatohepatitis (MASH) represents a growing clinical burden with increasing prevalence and lacking approved pharmacological therapies.
Xuhao Ni +7 more
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Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found [PDF]
BMC BiologyBackground Interferon regulatory factors (IRFs) are a family of transcription factors with important functions in immunity. The genomes of most vertebrates encode ten IRF genes.
Lenka Ungrová +13 more
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Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice [PDF]
Critical Care ExplorationsCONTEXT:. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019, causing the COVID-19 pandemic. While most infected people experienced mild illness, others progressed to severe disease, characterized by hyperinflammation and ...
Wendy E. Walker, PhD +6 more
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