Results 41 to 50 of about 5,868,061 (290)

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection

Cell Reports, 2020
Summary: Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and ...
Aaron T. Irving, Qian Zhang, Pui-San Kong, Katarina Luko, Pritisha Rozario, Ming Wen, Feng Zhu, Peng Zhou, Justin H.J. Ng, Radoslaw M. Sobota, Lin-Fa Wang   +10 more
doaj   +1 more source

Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape [PDF]

, 2003
Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1
Bossert, Birgit
core   +1 more source

Inducible Processing of Interferon Regulatory Factor-2 [PDF]

Molecular and Cellular Biology, 1992
PRDI-BFc and PRDI-BFi are proteins that bind specifically to a regulatory element required for virus induction of the human beta interferon (IFN-beta). PRDI-BFc is a constitutive binding activity, while the PRDI-BFi binding activity is observed only after cells are treated with inducers such as virus or poly(I).poly(C) plus cycloheximide or in some ...
V J, Palombella, T, Maniatis
openaire   +2 more sources

The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9

Cells, 2019
Interferon (IFN) β and Tumor Necrosis Factor (TNF) are key players in immunity against viruses. Compelling evidence has shown that the antiviral and inflammatory transcriptional response induced by IFNβ is reprogrammed by crosstalk with TNF ...
Mélissa K. Mariani, Pouria Dasmeh, Audray Fortin, Elise Caron, Mario Kalamujic, Alexander N. Harrison, Diana I. Hotea, Dacquin M. Kasumba, Sandra L. Cervantes-Ortiz, Espérance Mukawera, Adrian W. R. Serohijos, Nathalie Grandvaux   +11 more
doaj   +1 more source

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Journal of Pharmacological Sciences, 2015
Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes.
Takahiro Masuda, Shosuke Iwamoto, Satsuki Mikuriya, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inoue   +6 more
doaj   +1 more source

TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells

The Scientific World Journal, 2012
Tumour necrosis factor-α, interferon-γ and interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours.
Wenyi Gu, Jiezhong Chen, Lei Yang, Kong-Nan Zhao   +3 more
doaj   +1 more source

Rotavirus Antagonism of the Innate Immune Response

Viruses, 2009
Rotavirus is a primary cause of severe dehydrating gastroenteritis in infants and young children. The virus is sensitive to the antiviral effects triggered by the interferon (IFN)-signaling pathway, an important component of the host cell innate immune ...
Michelle M. Arnold, John T. Patton
doaj   +1 more source

Structural insights into interferon regulatory factor activation [PDF]

Cellular Signalling, 2010
The interferon regulatory factors (IRFs) play important roles in development of the immune system and host defense. Recent crystallographic and biochemical studies have provided insights into the mechanism of activation of IRFs by phosphorylation. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of ...
Weijun, Chen, William E, Royer
openaire   +2 more sources

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis [PDF]

, 2013
Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory ...
Schuerwegh, A. J., Alexander Kreuter (592), Herrick Ariane, Martín J., Carmona, F.D., Jacob M van Laar, Madelon C Vonk, Voskuyl AE, Denton C, Mónica Fernández-Castro, Martin Jose-Ezequiel, Hunzelmann Nicolas, Airó Paolo, Ariane Herrick (214049), Claudio Lunardi (12868), Paul Shiels (276244), Witte, T. de, Voskuyl Alexandre E., Distler, J.H., Riemekasten, Gabriela, H W Distler, Egurbide, María Victoria, Mónica Fernández-Castro (276238), Radstake TR, Camps, M.T., Egurbide, M. V., Simeón, C.P., Carreira, Patricia E., Airó, P., Kreuter, Alexander, Camps María Teresa, Airó, Paolo, Scorza, Raffaella, Martín, Javier, the Spanish Scleroderma Group, Nicolas Hunzelmann, Beltrán Emma, Madelon C. Vonk (213950), Torsten Witte, Javier Martín (2584444), Sáez-Comet, Luis, van Laar, J.M., María Teresa Camps, Callejas, J.L., Carmen Fonseca (214061), Airó P, Martin, J.E., Madhok, Rajan, Fernández Castro M, Kreuter, A., Herrick A, Carmen P. Simeón (5650816), Riemekasten Gabriela, Beltrán E, Radstake, T. R., Shiels, Paul G., Alexandre E. Voskuyl (213961), Carreira, P.E., Vonk, M.C., Lorenzo Beretta, Carreira PE, Hunzelmann N, Kreuter A, Patricia E. Carreira (276236), Beltrán, Emma, Carmona F. David, Rajan Madhok, Worthington J, Gabriela Riemekasten, Scorza R, Vonk MC, Simeón Carmen P., Witte, Torsten, Camps, María Teresa, Carmona FD, Herrick, A., Schuerwegh AJ, Paolo Airó, Distler, Jörg H W, Radstake Timothy R. D. J., Alexandre E Voskuyl, et al., José Luis Callejas (276237), Schuerwegh, Annemie J, Jane Worthington, Laar, Jacob M. van, Madhok R, Callejas, José Luis, Martín, J. E., Jacob M. van Laar (177818), Vonk Madelon C., Javier Martín, Beretta, Lorenzo, Emma Beltrá, Timothy R. D. J. Radstake (168224), Shiels Paul, Jörg H. W. Distler (3196062), Madhok Rajan, Callejas JL, Beltrán, E., Martin, Jose Ezequiel, Schuerwegh, A.J., Witte Torsten, Distler, J.H. W., Raffaella Scorza, Voskuyl, Alexandre E., Carmen P Simeón, Carmona, F David, Spanish Scleroderma, Claudio Lunardi, Rajan Madhok (23535), Group ", Voskuyl, A.E., Worthington, Jane, Egurbide, M.V., Jörg H W Distler, Saez-Comet, L., Callejas-Rubio, José Luis, Voskuyl, Alexandre E, van Laar JM, Simeón, Carmen P., Gabriela Riemekasten (276243), Denton, Christopher, Schuerwegh Annemie J., Camps MT, Paolo Airó (5650819), Witte T, Carmona, Francisco David, Denton, C., Lunardi, C., Fernández-Castro Mónica, Simeón, Carmen P, Riemekasten G, Luis Sáez-Comet (276239), Fonseca Carmen, Fernández-Castro, M., Herrick, Ariane, Timothy R D J Radstake, Scorza, R., Madhok, R., Denton Christopher, Fonseca, Carmen, Beretta L, Christopher Denton, Luis Sá Ez-Comet, Worthington, J., José Luis Callejas, Beretta, L., Annemie J Schuerwegh, Kreuter Alexander, Simeón CP, Nicolas Hunzelmann (213980), Lunardi Claudio, Jane Worthington (23502), Torsten Witte (32240), Emma Beltrán (276240), Lunardi, Claudio, Shiels, P., Carreira Patricia E., Fonseca C, Sáez Comet L, Shiels, Paul, Martín, J., Carmen Fonseca, F. David Carmona (276235), Riemekasten, G., Witte, T., Luis Sáez-Comet, Radstake, Timothy R. D. J., Jö Rg, van Laar, Jacob M., Egurbide María Victoria, Fernández-Castro, Monica, Radstake, T.R.D.J., van Laar Jacob M., Ariane Herrick, Emma Beltrán, Christopher Denton (276245), Alexander Kreuter, Martín Javier, Mó Nica Ferná Ndez-Castro, Shiels P, Vonk, Madelon C, Carreira, Patricia E, Fonseca, C., Paul Shiels, Callejas José Luis, Carmen P Simeó N, Martin JE, Lorenzo Beretta (214056), Egurbide MV, Distler Jörg H. W., Raffaella Scorza (214013), Vonk, Madelon C., María Victoria Egurbide, Hunzelmann, Nicolas, Carmona, F. David, Schuerwegh, Annemie J., Jose-Ezequiel Martin, Beretta Lorenzo, Patricia E Carreira, María Teresa Camps (276241), Scorza Raffaella, Annemie J. Schuerwegh (213966), Sáez-Comet Luis, F David Carmona, María Victoria Egurbide (276242), Laar, J.M. van, Hunzelmann, N., Worthington Jane, Martin, Jose-Ezequiel, van Laar, Jacob M, Spanish Scleroderma Group, Jose-Ezequiel Martin (213926), Distler JH, Radstake, Timothy R D J, Distler, Jörg H. W., Camps, Teresa   +217 more
core   +1 more source

Interferon regulatory factors in human lupus pathogenesis [PDF]

Translational Research, 2011
Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that results from both genetic predisposition and environmental factors. Many lines of investigation support interferon alpha (IFN-α) as a causal agent in human lupus, and high levels of serum IFN-α are a heritable risk factor for SLE. Interferon regulatory factors (IRFs) are
Rafah, Salloum, Timothy B, Niewold
openaire   +2 more sources