Results 61 to 70 of about 5,868,061 (290)

Identification of the DNA sequence interacting with Kaposis sarcoma-associated herpesvirus viral interferon regulatory factor 1 [PDF]

, 2007
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal ...
Yoo, Seung-Min, Lee, Daeyoup, Lee, Myung-Shin, Jeong, Kwi Wan, Choe, Joonho, Seo, Taegun, Park, Junsoo   +6 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Comparative analysis of the impact of interferon regulatory factors on basal and induced interferon and interferon stimulated gene expression in human and canine keratinocytes

Frontiers in Immunology
IntroductionKeratinocytes are key barrier cells able to mount a robust interferon (IFN) antiviral response to defend against infection in the skin. Similar to humans, dogs spontaneously develop skin disorders associated with dysregulation of IFN immunity
Sarah Quinlan, Susan May, Ryan Weeks, Jennifer Luff   +3 more
doaj   +1 more source

Bim nuclear translocation and inactivation by viral interferon regulatory factor.

PLoS Pathogens, 2010
Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of the host cell.
Young Bong Choi, John Nicholas
doaj   +1 more source

Interferon regulatory factor 5 and autoimmune lupus [PDF]

Expert Reviews in Molecular Medicine, 2013
Systemic lupus erythematosus (SLE) is a severe multi-system autoimmune disease, whereas interferon regulatory factor (IRF) 5 belongs to the family of transcription factors that modulate immune system activities. Recently, many lines of investigations suggested that IRF5 gene polymorphisms are closely associated with the disease onset of SLE.
Xu, W-D, Pan, H-F, Xu, Y, Ye, D-Q
openaire   +3 more sources

Interferon regulatory factor-8 suppresses osteoclastogenesis

, 2010
To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members--RANK, its ligand RANKL and its decoy receptor osteoprotegrin.
Wagner, H, Hermann Wagner
core   +1 more source

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques [PDF]

, 2022
Aims: Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state.
Singh, Pratibha, Nilsson, Jan, Edsfeldt, Andreas, Dib, Lea, Goddard, Michael E, Udalova, Irina, Borges, Patricia Das Neves, Orho-Melander, Marju, Volkov, Petr, Nitulescu, Mihaela, Lee, Regent, Goncalves, Isabel, Al-Sharify, Dania, Cole, Jennifer E., Goddard, Michael E., Cole, Jennifer E, Monaco, Claudia, Park, Inhye, Das Neves Borges, Patricia, Kassiteridi, Christina, Swart, Maarten, Sun, Jiangming, Persson, Ana, Maegdefessel, Lars, Edsfeldt, Andreas,, Cole, JE, Al-Sharify, Dania,, Udalova, Irina,, Persson, Ana,, Swart, M, Volkov, Petr,, Edsfeldt, Andreas;Swart, Maarten;Singh, Pratibha;Dib, Lea;Sun, Jiangming;Cole, Jennifer E;Park, Inhye;Al-Sharify, Dania;Persson, Ana;Nitulescu, Mihaela;Borges, Patricia Das Neves;Kassiteridi, Christina;Goddard, Michael E;Lee, Regent;Volkov, Petr;Orho-Melander, Marju;Maegdefessel, Lars;Nilsson, Jan;Udalova, Irina;Goncalves, Isabel;Monaco, Claudia, Maegdefessel, Lars,, Al-Sharify, D, Persson, A, Orho-Melander, Marju,, Singh, P, Dib, L, Sun, Jiangming,, Nilsson, Jan,, Cole, Jennifer E,, Nitulescu, Mihaela,, Monaco, Claudia,, Lund University., Park, Inhye,, Kassiteridi, Christina,, Edsfeldt, A, Goncalves, Isabel,, Nitulescu, M, Swart, Maarten,, Goddard, Michael E,, Das Neves Borges, Patricia,, Sun, J, Dib, Lea,, Lee, Regent,, Singh, Pratibha,, Park, I, Lars Maegdefessel, Marju Orho-Melander, Inhye Park, Dania Al-Sharify, Pratibha Singh, Patricia Das Neves Borges, Ana Persson, Isabel Goncalves, Claudia Monaco, Mihaela Nitulescu, Lea Dib, Jiangming Sun, Michael E Goddard, Andreas Edsfeldt, Jennifer E Cole, Christina Kassiteridi, Regent Lee, Irina Udalova, Maarten Swart, Jan Nilsson, Petr Volkov   +77 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon
Hindle, Laura, L. M. Butler, K. Shah, Hindle, L, Lowry, K, S. A. Chanas, Mutocheluh, Mohamed, K. Lowry, Lowry, K., Shah, K., Chanas, Simon, Chanas, SA, D. J. Blackbourn, Areste, C., M. Mutocheluh, Aresté, C, Butler, Lucilla, Butler, LM, Shah, K, Blackbourn, DJ, L. Hindle, Blackbourn, David, C. Aresté, Chanas, S. A., Lowry, Kym, Mutocheluh, M, Blackbourn, D. J., Mutocheluh, M., Evans, DJ, Evans, David J., D. J. Evans, Hindle, L., Evans, D. J., Butler, L. M., Evans, D. J.; id_orcid   +34 more
core   +2 more sources