Results 81 to 90 of about 5,868,061 (290)

Protective Role of the Host Innate Immune System in Prion Pathogenesis [PDF]

, 2019
Prion diseases, including human Creutzfeldt-Jakob disease, are infectious, intractable central neurodegenerative diseases, which are also zoonoses that commonly infect not only higher organisms but also a wide variety of animals.Pathogenic prions induce
石橋, 大輔
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

Frontiers in Immunology
IntroductionUltraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I interferons (IFNs) that promote increased keratinocyte (KC) death after UV ...
Shannon N. Loftus, Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg, J. Michelle Kahlenberg   +11 more
doaj   +1 more source

Functional analysis of a dominant negative mutation of interferon regulatory factor 5. [PDF]

PLoS ONE, 2009
BACKGROUND: Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation. Activation of IRF-5 results in the production
Long Yang, Tiejun Zhao, Xiaoliu Shi, Peyman Nakhaei, Yunling Wang, Qiang Sun, John Hiscott, Rongtuan Lin   +7 more
doaj   +1 more source

Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis [PDF]

Cell Metabolism, 2008
We have sought to identify transcriptional pathways in adipogenesis using an integrated experimental and computational approach. Here, we employ high-throughput DNase hypersensitivity analysis to find regions of altered chromatin structure surrounding key adipocyte genes.
Eguchi, Jun, Yan, Qing-Wu, Schones, Dustin E., Kamal, Michael, Hsu, Chung-Hsin, Zhang, Michael Q., Crawford, Gregory E., Rosen, Evan D.   +7 more
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Molecular characterization and antiviral effects of canine interferon regulatory factor 1 (CaIRF1)

BMC Veterinary Research, 2022
Background Interferon regulatory factor 1 (IRF1) is an important transcription factor that activates the type I interferon (IFN-I) response and plays a vital role in the antiviral immune response.
Xiangqi Hao, Hui Chen, Yanchao Li, Bo Chen, Weifeng Liang, Xiangyu Xiao, Pei Zhou, Shoujun Li   +7 more
doaj   +1 more source

Interferon regulatory factor 3 in adaptive immune responses.

, 2014
Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells.
Ysebrant De Lendonck, Laure, Martinet, Valérie, Goriely, Stanislas   +2 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism [PDF]

, 2010
This work is supported by UK MRC and BBRCBunyamwera virus NSs protein is involved in the inhibition of cellular transcription and the interferon (IFN) response, and it interacts with the Med8 component of Mediator.
Van Knippenberg, Ingeborg Christine, Carlton-Smith, C., Carlton-Smith, Charles, Elliott, Richard Michael, van Knippenberg, I., Elliott, R.M.   +5 more
core   +1 more source