Results 101 to 110 of about 5,868,061 (290)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. [PDF]

, 2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial ...
Elizabeth King, King, Elizabeth, Jarman, Elizabeth, Hazel M. Dockrell, Lifted Sichali, Fine, Paul E.M., Blackwell, Jenefer M., Weir, Rosemary E., Elizabeth Jarman, Sally Stenson, Nazareth, Bernadette, Warndorff, David K., Crampin, Amelia C, Black, Gillian F, Stenson, Sally, Mwaungulu, Lorren, Amelia C. Crampin, Linda Donovan, Blackwell, Jenefer M, Rosemary E. Weir, Paul E. M. Fine, Sian Floyd, Bernadette Nazareth, Fine, Paul EM, David K. Warndorff, Black, Gillian F., Crampin, Amelia C., Dockrell, Hazel M., Jenefer M. Blackwell, Floyd, Sian, Chaguluka, Steven D, Lorren Mwaungulu, Sichali, Lifted, Donovan, Linda, Steven D. Chaguluka, Warndorff, David K, Weir, Rosemary E, Chaguluka, Steven D., Dockrell, Hazel M, Ngwira, Bagrey, Bagrey Ngwira, Gillian F. Black   +41 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis

, 2013
We previously showed that a fish interferon (IFN) regulatory factor 9 (IRF9) homologue, crucian carp Carassius auratus IRF9, displays constitutively nuclear localization and involvement in fish IFN-dependent JAK-STAT signaling; however, little is known ...
Zhang, Yi-Bing, Zhang, Jian-She, Shi, Jun, Gui, Jian-Fang, Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.   +4 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Interferon regulatory factor signaling in autoimmune disease

Cytokine, 2017
Interferon regulatory factors (IRFs) play critical roles in pathogen-induced innate immune responses and the subsequent induction of adaptive immune response. Dysregulation of IRF signaling is therefore thought to contribute to autoimmune disease pathogenesis.
Bharati, Matta, Su, Song, Dan, Li, Betsy J, Barnes   +3 more
openaire   +3 more sources

Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]

, 2014
This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E, Smith, Matt, Killip, Marian J, Jackson, David, Randall, Richard E; id_orcid   +4 more
core   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer

Frontiers in Cell and Developmental Biology
IntroductionProgrammed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration.
Wenxuan Fu, Wenxuan Fu, Xiaomeng Chang, Xiaomeng Chang, Xiaomeng Chang, Kun Ye, Kun Ye, Zige Zheng, Zige Zheng, Qianyi Lai, Qianyi Lai, Minyang Ge, Minyang Ge, Yan Shi, Yan Shi, Yan Shi   +15 more
doaj   +1 more source