Results 91 to 100 of about 5,868,061 (290)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Journal of Ginseng Research, 2017
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects ...
Tao Yu, Yanyan Yang, Yi-Seong Kwak, Gwan Gyu Song, Mi-Yeon Kim, Man Hee Rhee, Jae Youl Cho   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

IKKε isoform switching governs the immune response against EV71 infection

Communications Biology, 2021
Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7).
Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen, Sui-Yuan Chang, Yao-Ting Huang, Bing-Ching Ho, Sung-Liang Yu   +6 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus

Clinical and Developmental Immunology, 2012
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the production of autoantibodies against components of the cell nucleus.
Candace M. Cham, Kichul Ko, Timothy B. Niewold   +2 more
doaj   +1 more source

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia

Journal of Neuroinflammation, 2012
Background Recent fate-mapping studies establish that microglia, the resident mononuclear phagocytes of the CNS, are distinct in origin from the bone marrow-derived myeloid lineage. Interferon regulatory factor 8 (IRF8, also known as interferon consensus
Horiuchi Makoto, Wakayama Kouji, Itoh Aki, Kawai Kumi, Pleasure David, Ozato Keiko, Itoh Takayuki   +6 more
doaj   +1 more source

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo [PDF]

, 2008
The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with adenoviral vectors.
György Fejer, Hildenbrand, B., Schleicher, U, Hildenbrand, Bernd, Marina A Freudenberg, Fejer, G., Greber, U., Ruzsics, Zsolt, Drechsel, Lisa, Fejer György, Imelli, N., Imelli, N, Ruzsics, Z., Krug Anne, Christian Bogdan, Keck, S., Zsolt Ruzsics, Lisa Drechsel, Hildenbrand Bernd, Drechsel, L., Simone Keck, Schleicher, Ulrike, Bogdan, C, Liese, J., Freudenberg, M., Bogdan, C., Schleicher Ulrike, Bogdan Christian, Ulrike Schleicher, Keck Simone, Krug, A., Fejer, György, Schleicher, U., Bogdan, Christian, Greber Urs F., Freudenberg, M A, Nicola Imelli, Krug, A, Greber, Urs F., Drechsel Lisa, Keck, S, Liese Jan, Krug, Anne, Jan Liese, Drechsel, L, Ruzsics, Z, Ruzsics Zsolt, Hildenbrand, B, Imelli, Nicola, Freudenberg, Marina A., Freudenberg Marina A., Bernd Hildenbrand, Urs F Greber, Fejer, G, Liese, J, Keck, Simone, Anne Krug, Greber, U F, Imelli Nicola, Liese, Jan   +59 more
core   +2 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source