Results 51 to 60 of about 5,868,061 (290)
SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3
Frontiers in Cellular and Infection Microbiology, 2022 Corona virus disease 2019 (COVID-19) pathogenesis is intimately linked to the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and disease severity has been associated with compromised induction of type I interferon (IFN-I) cytokines which ...
Raul S. Freitas +2 more
doaj +1 more source
Interferon Regulatory Factor 1 in Mycobacterial Infection [PDF]
Microbiology and Immunology, 2002 AbstractIn order to understand the role of IRF‐1 in the development of murine tuberculosis in vivo, IRF‐1 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. These knockout mice developed multifocal necrotic lesions in the lung, liver and spleen tissues and died of ...
Hiroyuki, Yamada +2 more
openaire +2 more sources
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. [PDF]
, 2016 UNLABELLED Interferon regulatory factor 3 (IRF3) is a transcription factor involved in the activation of type I alpha/beta interferon (IFN-α/β) in response to viral infection.
Ruggli, Nicolas +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The role of interferon regulatory factors in atherosclerosis
Frontiers in Cardiovascular MedicineCardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, largely driven by the progression of atherosclerotic plaques. In atherosclerosis (AS), transcription factors and epigenetic mechanisms play pivotal roles in regulating gene expression.
Wang, Yingsong +3 more
openaire +2 more sources
Interferon Regulatory Factors in Heart [PDF]
Hypertension, 2014 See related article, p 713–722 Cardiac hypertrophy and pathological remodeling are hallmarks of cardiomyopathy associated with many pathological stressors, such as mechanic overload, oxidative injury, hormonal stimulation, or viral infection. Transcriptional regulation is key to this process, involving well-established transcription factors, such as ...
Haipeng, Sun, Yibin, Wang
openaire +2 more sources
Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures
, 2021 Introduction Chronic rhinosinusitis is currently classified into two types: chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps.
Júlio Cláudio Sousa (12651722) +5 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. [PDF]
PLoS Pathogens, 2012 Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells.
Ami A Patel +4 more
doaj +1 more source
Interferon regulatory factor 6 determines intestinal epithelial cell development and immunity [PDF]
Interferon regulatory factor 6 plays a significant role in the regulation of intestinal epithelial cell identity, interferon response, and ...
Nice, Timothy J., Wright, Austin
core +1 more source