Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
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Activation of interferon regulatory factor 5 by site specific phosphorylation. [PDF]
PLoS ONE, 2012 The cellular defense to infection depends on accurate activation of transcription factors and expression of select innate immunity genes. Interferon regulatory factor 5 (IRF5), a risk factor for systemic lupus erythematosus, is activated in response to ...
Hui-Chen Chang Foreman +3 more
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Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response
Microbiology Spectrum, 2023 Enterovirus D68 (EV-D68) is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The protease from EV-D68 could impair type I interferon (IFN-I) production.
Jun Kang +8 more
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The growing family of interferon regulatory factors
Cytokine & Growth Factor Reviews, 1997 Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well ...
H, Nguyen, J, Hiscott, P M, Pitha
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Phosphorylation of interferon regulatory factor 9 (IRF9)
Molecular Biology Reports, 2023 IRF9 is a transcription factor that mediates the expression of interferon-stimulated genes (ISGs) through the Janus kinase-Signal transducer and activator of transcription (JAK-STAT) pathway. The JAK-STAT pathway is regulated through phosphorylation reactions, in which all components of the pathway are known to be phosphorylated except IRF9. The enigma
Alvin Paul +3 more
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CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]
, 2010 Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA +23 more
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Silencing of interferon regulatory factor gene 6 in melanoma.
PLoS ONE, 2017 BackgroundMethylation of a CpG island (CGI; a dense cluster of CpGs) located in the 5' region of a gene suppresses transcription of that gene. Interferon regulatory factor 6 (IRF6) is associated with the expression of interferon, which is used as an ...
Yoshimasa Nobeyama, Hidemi Nakagawa
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Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
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Identification of Proteins Immunologically Related to Interferon Regulatory Factor–1 That Bind with Interferon Regulatory Factor Element [PDF]
The Journal of Infectious Diseases, 2006 Interferon regulatory factor (IRF)-1 expression was surveyed in nontransformed and oncogene-transformed mouse fibroblasts, using Western immunoblot with an IRF-1-specific antiserum, to examine possible differences resulting from cellular transformation. Ten additional proteins that reacted with the IRF-1 antibody and that underwent specific competition
Sara, Contente +2 more
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Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]
, 2008 Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat +7 more
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