Results 11 to 20 of about 5,868,061 (290)
Poxviral Targeting of Interferon Regulatory Factor Activation [PDF]
Viruses, 2020 As viruses have a capacity to rapidly evolve and continually alter the coding of their protein repertoires, host cells have evolved pathways to sense viruses through the one invariable feature common to all these pathogens—their nucleic acids.
Clara Lawler, Gareth Brady
doaj +7 more sources
Interferon regulatory factor 7 in inflammation, cancer and infection [PDF]
Frontiers in Immunology, 2023 Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-
Furong Qing, Zhiping Liu
doaj +2 more sources
Rhadinoviral interferon regulatory factor homologues
Biological Chemistry, 2017 Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral ...
Sandra Koch, Thomas F. Schulz
openaire +3 more sources
Activation and Function of Interferon Regulatory Factor 5
Journal of Interferon & Cytokine Research, 2015 Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. Upon induction of immune signaling pathways, IRF5 undergoes post-translational modifications such as phosphorylation and ubiqutination, which are believed to ...
Ryzhakov, G, Eames, H, Udalova, I
openaire +3 more sources
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3 [PDF]
Frontiers in Immunology, 2017 The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type I interferon response and induce antiviral effects.
Chenyang Yi +31 more
doaj +2 more sources
A hyperactive mutant of interferon‐regulatory factor 4
European Journal of Immunology, 2018 We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon-regulatory factor) C-terminus creates hyperactive IRF4. When introduced into IRF4-deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4.
Chol Ho Kang +11 more
openaire +3 more sources
Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation [PDF]
Veterinary ResearchGetah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Hua Liu +14 more
doaj +2 more sources
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells. [PDF]
PLoS BiologyMultiple myeloma (MM) arises through oncogenic transformation of immunoglobulin-secreting plasma cells. MM often co-opts the central endoplasmic reticulum (ER)-stress mitigator, inositol-requiring enzyme 1 (IRE1), to sustain malignant growth.
Ioanna Oikonomidi +9 more
doaj +2 more sources
The multiple roles of interferon regulatory factor family in health and disease [PDF]
Signal Transduction and Targeted TherapyInterferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes.
Lian Wang +9 more
doaj +2 more sources
Interferons and Interferon Regulatory Factors in Malaria [PDF]
Mediators of Inflammation, 2014 Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies.
Sin Yee Gun +3 more
openaire +4 more sources