Results 21 to 30 of about 5,868,061 (290)

Viral Interferon Regulatory Factors [PDF]

Journal of Interferon & Cytokine Research, 2009
Upon viral infection, the major defensive strategy employed by the host immune system is the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN regulatory factors (IRFs). In order to complete their life cycles, viruses must find a way to modulate the host IFN-mediated immune response.
Hye-Ra, Lee, Myung Hee, Kim, Jong-Soo, Lee, Chengyu, Liang, Jae U, Jung   +4 more
openaire   +2 more sources

Interferon Regulatory Factor 3 (IRF3) Characterisation in Four Mammalian Species Using Bioinformatics Method

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies, 2021
IRF3 has gained recognition as a key transcriptional regulator of type1 interferon (IFN) gene expression which induces response to pathogenic infection.
Sanda MOFOYEKE, Adenaike ADEYEMI, Fafiolu ADEBOYE, Adeyinka SANDA, Christian IKEOBI   +4 more
doaj   +1 more source

Interferon Regulatory Factor 5 Mediates Lipopolysaccharide-Induced Neuroinflammation

Frontiers in Immunology, 2020
BackgroundActivated microglia play a vital role in neuroinflammation in the central nervous system (CNS), which is associated with the pathogenesis and the progression of neurological diseases.
Ziqi Fan, Shuai Zhao, Yueli Zhu, Yueli Zhu, Zheyu Li, Zhirong Liu, Yaping Yan, Jun Tian, Yanxing Chen, Baorong Zhang   +9 more
doaj   +1 more source

Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1

Autophagy Reports, 2023
Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj   +1 more source

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.), Sadik, Christian David, Bachmann, Malte, Mühl, Heiko   +3 more
core   +1 more source

Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection [PDF]

, 2012
Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE).
Yamaguchi, Naohiro, Satoh, Katsuya, Fuse, Takayuki, Nishida, Noriyuki, Ishibashi, Daisuke, Atarashi, Ryuichiro, Nakagaki, Takehiro, Honda, Kenya   +7 more
core   +1 more source

Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription.

PLoS ONE, 2020
Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin resistance and obesity-related-health problems.
Masashi Kuroda, Misa Nishiguchi, Naho Ugawa, Etsuko Ishikawa, Yasuyo Kawabata, Saya Okamoto, Waka Sasaki, Yumiko Miyatake, Mayu Sebe, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada, Hiroshi Sakaue   +12 more
doaj   +1 more source

IRF1 (interferon regulatory factor 1) [PDF]

, 2008
Review on IRF1 (interferon regulatory factor 1), with data on DNA, on the protein encoded, and where the gene is ...
Palladinetti, P, A Dolnikov, G Symonds, Symonds, G, Dolnikov, A, P Palladinetti   +5 more
core   +1 more source

IRF4 (interferon regulatory factor 4) [PDF]

, 2009
Review on IRF4 (interferon regulatory factor 4), with data on DNA, on the protein encoded, and where the gene is ...
Rasi, S, Gaidano, G
core   +1 more source

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.

PLoS Pathogens, 2021
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes.
Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M Lemon, Daisuke Yamane   +4 more
doaj   +1 more source