Results 261 to 270 of about 1,888,881 (401)

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

The role of M2 proteins of pneumoviruses in transcription regulation, prevention of hypermutation, and activation of the type I interferon pathway

Pau Ribó-Molina, Kevin Groen, Balasubramanian Susma, Stefan van Nieuwkoop, Mathis Funk, Ron A. M. Fouchier, Bernadette van den Hoogen   +6 more
openalex   +1 more source

Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus [PDF]

, 2019
Uma Thanarajasingam, Anoohya N. Muppirala, Mark A. Jensen, Yogita Ghodke‐Puranik, Jessica M. Dorschner, Danielle Vsetecka, Shreyasee Amin, Ashima Makol, Floranne C. Ernste, Thomas G. Osborn, Kevin G. Moder, Vaidehi Chowdhary, Timothy B. Niewold   +12 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Correction: Type I Interferon: Potential Therapeutic Target for Psoriasis?

PLoS ONE, 2009
Yihong Yao, Laura Richman, Chris Morehouse, Melissa de los Reyes, Brandon W. Higgs, Anmarie Boutrin, Barbara White, Anthony Coyle, James Krueger, Peter A. Kiener, Bahija Jallal   +10 more
doaj   +3 more sources

PO:25:079 | Anifrolumab in refractory dermatomyositis: a case report

Reumatismo
Background. Dermatomyositis is a rare autoimmune disease characterized by multisystem involvement. Treatment can be challenging, particularly in refractory cases unresponsive to conventional therapies, for which standardized management protocols are ...
Società Italiana di Reumatologia
doaj  

STING controls Herpes Simplex Virus in vivo independent of type I interferon induction [PDF]

, 2019
Lívia H. Yamashiro, Stephen C. Wilson, Huntly M. Morrison, Vasiliki Karalis, Jing-Yi J. Chung, Katherine J. Chen, Helen S. Bateup, Moriah L. Szpara, Angus Y. Lee, Jeffery S. Cox, Russell E. Vance   +10 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Reviewer #2 (Public Review): Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen   +13 more
openalex   +1 more source

Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon-inducible gene [PDF]

, 1988
Kerr, I M, Kerr, S M, Stark, G R
core   +1 more source