Results 271 to 280 of about 1,888,881 (401)

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Cell Host and Microbe, 2016
Rudragouda Channappanavar, Anthony R. Fehr, R. Vijay, M. Mack, Jincun Zhao, D. Meyerholz, S. Perlman   +6 more
semanticscholar   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Table 2_Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL.xlsx

Qirui Zhou (22853510), Ruinan Jia (11096451), Jinlin Chen (5225018), Yang Tan (151624), Yuechan Ma (16487724), Mengfan Luan (22853513), Xue Sheng (8834006), Xiao Han (102316), Shuying Li (354398), Fei Lu (102472), Chunyan Ji (443711), Dongmei Wang (282313), Jingjing Ye (84458)   +12 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank. [PDF]

Nat Commun
Rioux B, McGlasson S, Forbes D, Reid KR, Klingseisen A, Berry J, Dhaun N, Ng WF, Whiteley W, Hunt DPJ.   +9 more
europepmc   +1 more source

Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model

Jerrold S. Levine, Céleste Pilon, Rebecca Subang, David Salem, Elena Lonina, Salman Qureshi, Gregory J. Fonseca, Philippe Gros, Joyce Rauch   +8 more
openalex   +1 more source

Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity [PDF]

Telly Sepahpour, Jalal Alshaweesh, Nazli Azodi, Komudi Singh, Derek D.C. Ireland, Farzaneh Valanezhad, Risa Nakamura, Abhay R. Satoskar, Ranadhir Dey, Shinjiro Hamano, Hira L. Nakhasi, Sreenivas Gannavaram   +11 more
openalex   +1 more source

Type I interferon in organ-targeted autoimmune and inflammatory diseases [PDF]

, 2010
Mary K. Crow
openalex   +1 more source