Results 261 to 270 of about 332,508 (311)

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Modulation of Host Innate Immune Response by Highly Pathogenic Human Coronaviruses during Viral Infection. [PDF]

J Microbiol Biotechnol
Kim YJ, Lee SJ, Lee W, Kim SJ, Ahn DG.
europepmc   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

Transposable elements as a possible missing link between genetic predisposition and environmental triggers of autoimmune disorders: insights from type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis. [PDF]

Front Immunol
Mužina K, Vrhovšek AM, Bizjan BJ, Šamec N, Kovač J, Dovč K, Battelino T, Pokorn M.   +7 more
europepmc   +1 more source

Fangchinoline Activates cGAS-STING to Promote Antitumor Immunity without Pathological Inflammation. [PDF]

Int J Biol Sci
Zhao Y, Chen X, Xie Y, Liu T, Luo Y, Liu Z, Zhu Y, Chen L, Ren Y, Liu H, Zhao P, Wang Q, You F.   +12 more
europepmc   +1 more source

From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus. [PDF]

Int J Mol Sci
Rashid R, Ramirez-Ortiz ZG.
europepmc   +1 more source

Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination. [PDF]

Cell Death Dis
Liu Z, Li R, Fan C, Liu Y, Liu J, Yin M, Shang N, Wang X, Qi Z, Shen Y, Liu C.   +10 more
europepmc   +1 more source

Identification of extracellular vesicle microRNAs as potential facilitators of interferon-alpha escape in Marek's disease virus infection. [PDF]

Front Cell Infect Microbiol
Wei S, Zhao Z, Dou J, Gao W, Gao X, Wu T, Zhang Z, Liu X, Li Y.   +8 more
europepmc   +1 more source

Swine TRIM25 inhibits vesicular stomatitis virus replication by activation of type I IFN signaling pathway and binding vRNA. [PDF]

J Vet Sci
Cao Y, Zhang J, Yoo D, Zhang H, Jiang D, Hu Y, Cong X, Li J, Wu X, Du Y, Qi J, Huang J.   +11 more
europepmc   +1 more source

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Type I Interferons in Autoimmunity

Journal of Investigative Dermatology, 2022
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies ...
Ruth Fernandez-Ruiz, Timothy B. Niewold
openaire   +2 more sources