Results 31 to 40 of about 306,547 (146)

Regulation of type I interferon responses [PDF]

Nature Reviews Immunology, 2013
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).
Lionel B, Ivashkiv, Laura T, Donlin
openaire   +2 more sources

Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Pathogens, 2022
Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Čičin-Šain, Andrea Kröger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjörg Hauser, Mario Köster   +14 more
doaj   +1 more source

Type I interferon sensing unlocks dormant adipocyte inflammatory potential

Nature Communications, 2020
White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte ...
Calvin C. Chan, Michelle S. M. A. Damen, Maria E. Moreno-Fernandez, Traci E. Stankiewicz, Monica Cappelletti, Pablo C. Alarcon, Jarren R. Oates, Jessica R. Doll, Rajib Mukherjee, Xiaoting Chen, Rebekah Karns, Matthew T. Weirauch, Michael A. Helmrath, Thomas H. Inge, Senad Divanovic   +14 more
doaj   +1 more source

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]

PLoS Pathogens, 2011
Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, Ren Sun   +6 more
doaj   +1 more source

Interplay between SARS-CoV-2 and the type I interferon response.

PLoS Pathogens, 2020
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. An unbalanced immune response, characterized by a weak production of type I interferons (IFN-Is) and an exacerbated release of ...
Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux, Sébastien Nisole   +3 more
doaj   +1 more source

ULK1 in type I interferon response

Oncotarget, 2015
Type I interferon (IFN) signaling leads to transcription and translation of key IFN-stimulated genes (ISGs), whose protein products exhibit anti-tumorigenic, anti-viral, and immunomodulatory functions [1–3]. These responses are triggered by the interaction of type I IFNs (IFNα, IFNβ, IFNω) with a unique cell surface receptor composed by two subunits ...
Diana, Saleiro, Leonidas C, Platanias
openaire   +2 more sources

Immunomodulatory functions of type I interferons [PDF]

Nature Reviews Immunology, 2012
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these ...
González Navajas, José Manuel, Lee, Jongdae, David, Michael, Raz, Eyal   +3 more
openaire   +3 more sources

Central Role of ULK1 in Type I Interferon Signaling

Cell Reports, 2015
We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate that the function of ULK1 is required for gene transcription mediated via IFN-stimulated ...
Diana Saleiro, Swarna Mehrotra, Barbara Kroczynska, Elspeth M. Beauchamp, Pawel Lisowski, Beata Majchrzak-Kita, Tushar D. Bhagat, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Ewa M. Kosciuczuk, Darren P. Baker, Chunfa Jie, Nadereh Jafari, Craig B. Thompson, Ross L. Levine, Eleanor N. Fish, Amit K. Verma, Leonidas C. Platanias   +18 more
doaj   +1 more source

PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

Cell Reports
Summary: The regulation of type I interferon signaling is crucial for precisely tuning the innate immune response to combat pathogen invasions, fight cancer, and prevent autoimmune diseases.
Jiashu Xu, Tao Yu, Zongwei Yue, Xuan Lu, Yandong Zhang, Lei Wang, Samaneh Shabani Åhrling, Michael R. Smith, Yan Chun Li, Jason Matthews, Hening Lin   +10 more
doaj   +1 more source

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

Cell Reports, 2019
Summary: γ-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity.
Dapei Li, Rongsheng Wu, Wen Guo, Lifen Xie, Zigang Qiao, Shengchuan Chen, Jingfei Zhu, Chaohao Huang, Jian Huang, Bicheng Chen, Yanghua Qin, Feng Xu, Feng Ma   +12 more
doaj   +1 more source