Results 81 to 90 of about 1,888,881 (401)

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Nature Communications, 2022
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death.
Nikaïa Smith, C. Posseme, V. Bondet, J. Sugrue, L. Townsend, B. Charbit, V. Rouilly, Violaine Saint-André, Tom Dott, Andre Rodriguez Pozo, N. Yatim, O. Schwartz, Minerva Cervantes-Gonzalez, J. Ghosn, Paul Bastard, J. Casanova, T. Szwebel, B. Terrier, N. Conlon, C. O’Farrelly, C. N. Cheallaigh, Nollaig M. Bourke, D. Duffy   +22 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage [PDF]

, 2019
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to disease or death. However, it is unclear how the host immune system balances control of infection and protection from the collateral tissue damage.
Egawa, Takeshi, Raju, Saravanan, Verbaro, Daniel J   +2 more
core   +1 more source

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells [PDF]

, 2010
The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown.
Guérin, Jean-Luc, Soubiès, Sébastien, Volmer, Christelle, Volmer, Romain   +3 more
core   +1 more source

Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis

Clinical Microbiology Reviews, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. In
Santhamani Ramasamy, S. Subbian
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

ULK1 in type I interferon response

Oncotarget, 2015
Type I interferon (IFN) signaling leads to transcription and translation of key IFN-stimulated genes (ISGs), whose protein products exhibit anti-tumorigenic, anti-viral, and immunomodulatory functions [1–3]. These responses are triggered by the interaction of type I IFNs (IFNα, IFNβ, IFNω) with a unique cell surface receptor composed by two subunits ...
Diana, Saleiro, Leonidas C, Platanias
openaire   +2 more sources

Immunomodulatory functions of type I interferons [PDF]

Nature Reviews Immunology, 2012
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these ...
González Navajas, José Manuel, Lee, Jongdae, David, Michael, Raz, Eyal   +3 more
openaire   +3 more sources

Senegalese sole (Solea senegalensis) ISG15: molecular characterization and in vivo interplay with viral infections [PDF]

, 2015
The interferon-stimulated gene 15 (Isg15) is strongly induced by type I interferon (IFN I), viral infection, and double-stranded RNA (poly I:C) in several fish species, suggesting that Isg15 protein could play a key role in fish innate immunity against ...
Alonso-Sanchez, Maria del Carmen, Bandín, Isabel, Bejar-Alvarado, Julia, García-Rosado, Esther, Podadera, Ana María, Álvarez-Torres, Daniel   +5 more
core  

Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings [PDF]

, 2014
Cataloged from PDF version of article.Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications.
Gungor, B., Gursel, I., Gursel, M., Yagci, F. C.   +3 more
core   +1 more source