Results 101 to 110 of about 419,491 (364)
Responses to Cytokines and Interferons that Depend upon JAKs and STATs.
Cold Spring Harbor Perspectives in Biology, 2018 Many cytokines and all interferons activate members of a small family of kinases (the Janus kinases [JAKs]) and a slightly larger family of transcription factors (the signal transducers and activators of transcription [STATs]), which are essential ...
G. Stark, H. Cheon, Yuxin Wang
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Immunity, Inflammation and Disease, 2018 Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford +6 more
doaj +1 more source
Cytokines and Interferons: Types and Functions
Autoantibodies and Cytokines, 2018 This chapter aims to describe and review the main important cytokines types (notably interferons), including their biological activities, functions and structures.
V. L. Ferreira +4 more
semanticscholar +1 more source
Journal of General Virology, 1972 Summary The pre-treatment of mouse L cells with interferon or polyinosinic-polycytidylic acid potentiated the interferon response of these cells to subsequent stimulation with suboptimal doses of polyinosinic-polycytidylic acid. This potentiation was manifested as an earlier production of interferon, a faster attainment of maximum interferon production,
H. B. Levy, S. A. Margolis, H. Oie
openaire +3 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Brain-Derived Neurotrophic Factor in Multiple Sclerosis Disability: A Prospective Study
Brain SciencesMultiple sclerosis (MS) is a demyelinating central nervous system disease that leads to neurological disability. Brain-derived neurotrophic factors (BDNFs) are neurotrophins involved in neurodegenerative disorders.
Vitalie Vacaras +9 more
doaj +1 more source
mBio, 2019 Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear.
Jordan V. Price +7 more
doaj +1 more source
Stochastic model of virus and defective interfering particle spread across mammalian cells with immune response [PDF]
arXiv, 2011 Much of the work on modeling the spread of viral infections utilized partial differential equa- tions. Traveling-wave solutions to these PDEs are typically concentrated on velocities and their dependence on the various parameters. Most of the investigations into the dynamical interaction of virus and defective interfering particles (DIP), which are ...
arxiv
Dynamic change of gene-to-gene regulatory networks in response to SARS-CoV-2 infection [PDF]
arXiv, 2020 The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process is indispensable for an understanding of how SARS-CoV-2 behaves in human host cells. However, little is known about
arxiv