Results 41 to 50 of about 136,515 (265)

Flexible designs of clinical trials – a graphical representation in form of a chance tree

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2010
Background: Flexible design of clinical trials may allow tailoring ongoing investigations to better suit actual circumstances such as an unexpectedly low effect size without compromising error control properties.
Hellmich, Martin
doaj  

Modern Clinical Trials: Seamless Designs and Master Protocols

Cancer Medicine
Background Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease areas, this is particularly true for Phase II/III cancer clinical trials ...
Abigail Burdon, Thomas Jaki, Xijin Chen, Pavel Mozgunov, Haiyan Zheng, Richard Baird   +5 more
doaj   +1 more source

An interim analysis of the national treatment guideline for paediatric germ cell tumours and sex cord stromal tumours by the South African Association of Paediatric Haematology Oncology

South African Journal of Oncology
Background: The South African Association of Paediatric Haematology Oncology (SAAPHO) developed a national treatment guideline for children with benign and malignant extracranial germ cell tumours (MEGCTs) and sex cord stromal tumours (SCSTs), named ...
Marc Hendricks, Anel van Zyl, Jan du Plessis, Jennifer Geel, Gita Naidu, Bongiwe Radebe, Bulelwa Masoka, Karla Thomas, Rema Mathew, Kirsten A. Donald, Mariana Kruger   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Evaluation of ERA-40 and ERA-interim re-analysis incoming surface shortwave radiation datasets with mesoscale remote sensing data

Meteorologische Zeitschrift, 2010
In this paper an evaluation of the European Center for Medium Range Forecasting 40-year re-analysis (ERA-40) and interim re-analysis (ERA-Interim) solar irradiation datasets is presented.
Christine Träger-Chatterjee, Richard W. Müller, Jörg Trentmann, Jörg Bendix   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

THE SKATE STUDY: INTERIM ANALYSIS

International Journal of Clinical Practice, 2003
SUMMARYThe Safety of Keppra as Adjunctive Therapy in Epilepsy (SKATE) study is a continuing phase IV open‐label evaluation of the antiepileptic drug levetiracetam (Keppra) as an adjunctive therapy in adult patients with uncontrolled partial seizures.
Christian Elger, Ley Sander, Olwen Glynn Owen   +2 more
openaire   +3 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source