Results 31 to 40 of about 136,515 (265)

Predicting if Lung Cancer Will Relapse–The Role of Neutrophil/Lymphocyte Ratio

Hematology/Oncology and Stem Cell Therapy, 2023
Objective/Background: Baseline neutrophil/lymphocyte ratio (NLR), a surrogate marker for systemic inflammation and immunosuppression, is a well-studied prognostic marker in non-small cell lung cancer (NSCLC). This study tests if interim NLR is prognostic
Abigail Chan, Søren Bentzen, Amit Rout, Kenneth Miller   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Accelerate vaccine development using seamless phase 2/3 trial designs

Expert Review of Vaccines
Background Traditional vaccine development, often a lengthy and costly process of three separated phases. However, the swift development of COVID-19 vaccines highlighted the critical importance of accelerating the approval of vaccines.
Jia-Ying Yang, Guo-Chun Li, Ying Yuan
doaj   +1 more source

The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

BMC Medical Research Methodology, 2008
Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended ...
Hampton John, Calvert Melanie, Tharmanathan Puvan, Freemantle Nick   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Underuse of split-dose cisplatin in patients with moderate renal impairment may compromise optimal outcomes with avelumab maintenance in metastatic urothelial carcinoma: interim UROCAPOL registry data

Oncology in Clinical Practice
INTRODUCTION: Avelumab maintenance is the standard of care for patients with metastatic urothelial carcinoma (mUC) not progressing after first-line platinum-based chemotherapy.
Piotr J. Wysocki, Łukasz Kwinta, Anna Kostrzewska, Jakub Kucharz, Bożena Sikora-Kupis, Barbara Radecka, Małgorzata Talerczyk, Katarzyna Hetman, Magdalena Skórzewska, Lubomir Bodnar, Zbyszko Chowaniec, Magdalena Ciążyńska, Monika Olejniczak, Dawid Sigorski, Joanna Zyguła, Natalia Dzięgiel   +15 more
doaj   +1 more source

Evaluation of NCEP‐FNL and ERA‐Interim Data Sets in Detecting Tibetan Plateau Vortices in May–August of 2000–2015

Earth and Space Science, 2020
Tibetan Plateau vortices (TPVs) are important rainfall triggers in southwestern and eastern China after they move off the plateau. Characteristics of the moving‐off TPVs derived from two gridded data sets, the final operational global analysis data from ...
Lun Li, Renhe Zhang, Peili Wu
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source