Results 11 to 20 of about 136,515 (265)
Interim analysis: A rational approach of decision making in clinical trial
Journal of Advanced Pharmaceutical Technology & Research, 2016 Interim analysis of especially sizeable trials keeps the decision process free of conflict of interest while considering cost, resources, and meaningfulness of the project. Whenever necessary, such interim analysis can also call for potential termination
Amal Kumar, Bhaswat S Chakraborty
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A systematic survey of randomised trials that stopped early for reasons of futility
BMC Medical Research Methodology, 2020 Background Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead
S. D. Walter +7 more
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Adaptive designs in clinical trials
Perspectives in Clinical Research, 2011 In addition to the expensive and lengthy process of developing a new medicine, the attrition rate in clinical research was on the rise, resulting in stagnation in the development of new compounds.
Suresh Bowalekar
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Adaptive designs in critical care trials: a simulation study
BMC Medical Research Methodology, 2023 Background Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care ...
W. Li +4 more
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Age and renal transplantation: an interim analysis [PDF]
Nephrology Dialysis Transplantation, 2003 The life expectancy of the population in general is increasing consistently, as is the age of the dialysis population. Consequently, donors and recipients are getting older, and renal transplantation has become a therapy that is not limited to the youngest segment of subjects with terminal renal failure.
Gabriele, Schratzberger, Gert, Mayer
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Application of Adaptive Interim Analysis in Pharmacology [PDF]
Drug Information Journal, 1997 A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development.
Hothorn, Ludwig A., Martin, Ullrich
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Cancer Genome Sequencing—An Interim Analysis [PDF]
Cancer Research, 2009 Abstract With the publishing of the first complete whole genome of a human cancer and its paired normal, we have passed a key milestone in the cancer genome sequencing strategy. The generation of such data will, thanks to technical advances, soon become commonplace. As a significant number of proof-of-concept studies have been published,
Edward J, Fox +2 more
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Decision on performing interim analysis for comparative clinical trials
Contemporary Clinical Trials Communications, 2017 In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy.
Kyongsun Pak +2 more
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Cancer Imaging, 2023 Background To investigate the value of [18F]FDG-PET/MRI in predicting treatment response and survival in patients with primary M0 esophageal squamous cell carcinoma.
Yin-Kai Chao +7 more
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BMC Pediatrics, 2009 Background Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical impact of a trial. Our aim was to
van der Lee Johanna H +2 more
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