Results 101 to 110 of about 273,460 (262)

Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation

Frontiers in Immunology, 2020
The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death.
Yuki Sasaki, Kunihiro Otsuka, Hideki Arimochi, Shin-Ichi Tsukumo, Shin-Ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +7 more
doaj   +1 more source

Penurunan Kadar IL-1β Makrofag Terpapar Agregat Bakteri Actinomycetemcomitans Setelah Pemberian Minyak Atsiri Temu Putih [PDF]

, 2015
IL-1β level of macrophage exposed to A. actinomycetemomitans decreases after administration Curcuma Zedoaria volatile oil. Activation of interleukin-1β (IL-1β) is a key regulator of the inflammatory response.
Asih, R. (Ristini), Fatimah, S. (Siti), Handajani, J. (Juni), Latif, A. (Antinah)   +3 more
core   +4 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Serum interleukin 1β in patients with acquired laryngotracheal stenosis

Acta Otorhinolaryngologica Italica, 2022
Norazwani Azwal, Yogeswaran Lokanathan, Mawaddah Azman, Min Hwei Ng, Abdullah Sani Mohamed, Marina Mat Baki   +5 more
doaj   +1 more source

Applying Proteomics to Study Crosstalk at the Cartilage-Subchondral Bone Interface in Osteoarthritis: current Status and Future Directions [PDF]

, 2018
K
Fellows, Christopher R., Matta, Csaba, Mobasheri, Ali   +2 more
core   +1 more source

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

Advanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian, Iris E. Allijn, Laura Veenendaal, Nicole Bassous, Su Ryon Shin, Jeroen Leijten   +5 more
wiley   +1 more source

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Cell Reports, 2018
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis.
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder   +13 more
doaj   +1 more source

Evidence of association of the NLRP1 gene with giant cell arteritis [PDF]

, 2017
Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity.
Blanco, Ricardo, Boiardi, Luigi, Carmona, F. David, Castañeda, Santos, Cid Xutglà, M. Cinta, García-Villanueva, María Jesús, González-Gay, Miguel A., Gómez Vaquero, Carmen, Hernández Rodríguez, José, Hidalgo-Conde, Ana, Martín, Javier, Marí-Alfonso, Begoña, Miranda-Filloy, José A., Morado, Inmaculada C., Ortego Centeno, Norberto, Pazzola, Giulia, Prieto González, Sergio, Rodríguez-Rodríguez, Luis, Salvarani, Carlo, Serrano, Aurora, Solans, Roser, Sopeña, Bernardo, Sánchez-Martin, Julio, Unzurrunzaga, Ainhoa   +23 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Interleukin-1 (IL-1) system gene expression in granulosa cells: kinetics during terminal preovulatory follicle maturation in the mare

Reproductive Biology and Endocrinology, 2003
Background A growing body of evidences suggests that the ovary is a site of inflammatory reactions, and thus, ovarian cells could represent sources and targets of the interleukin-1 (IL-1) system.
Gérard Nadine, Martoriati Alain
doaj   +1 more source