Results 71 to 80 of about 273,460 (262)

How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta

, 2000
The overall structure of the transition state and intermediate ensembles experimentally observed for Dihydrofolate Reductase and Interleukin-1beta can be obtained utilizing simplified models which have almost no energetic frustration.
Alm, C. Clementi, Dill, Galzitskaya, Heidary, J. N. Onuchic, JONES, Jones, Jones, Klimov, Kuwajima, Leopold, Li, Mirny, Munoz, Nelson, Nymeyer, Onuchic, Onuchic, Onuchic, P. A. Jennings, Plaxco, Shea, Sobolev, Varley   +24 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Interleukin-1β gene is not associated with preeclampsia in Taiwanese

Taiwanese Journal of Obstetrics & Gynecology, 2012
Objective: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women. Methods and Materials: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β ...
Lin Kang, Chung-Hwan Chen, Chen-Hsiang Yu, Chiung-Hsin Chang, Fong-Ming Chang   +4 more
doaj   +1 more source

Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]

, 2018
The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core   +1 more source

The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells [PDF]

, 2008
Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix.
Corps, Anthony N., Curry, Valerie A., Harrall, Rebecca L., Hazleman, Brian L., Jones, Gavin C., Riley, Graham P.   +5 more
core   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)

Nutrition Journal, 2012
Background In vitro and animal studies have demonstrated that Chlorella is a potent biological response modifier on immunity. However, there were no direct evidences for the effect of Chlorella supplementation on immune/inflammation response in healthy ...
Kwak Jung, Baek Seung, Woo Yongje, Han Jae, Kim Byung Gon, Kim Oh, Lee Jong   +6 more
doaj   +1 more source

Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy

Бюллетень сибирской медицины, 2020
Aim. To study the relationship between the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in the acute period of ischemic stroke, and the strategy of reperfusion therapy.Materials and methods.
A. Yu. Bykova, A. A. Kulesh, N. A. Kayleva, E. M. Kuklina, V. V. Shestakov   +4 more
doaj   +1 more source

Febrile seizures: mechanisms and relationship to epilepsy. [PDF]

, 2009
Studies of febrile seizures have been driven by two major enigmas: first, how these most common of human seizures are generated by fever has not been known.
Alheim, Amy L. Brewster, Annegers, Annegers, Aram, Audenaert, Balestrino, Ban, Baram, Baram, Barone, Bender, Bender, Berg, Berg, Berg, Berg, Berg, Brewster, Brewster, Cartmell, Cartmell, Cendes, Chang, Chen, Chen, Chen, Céline M. Dubé, Dubé, Dubé, Dubé, Dubé, Dzhala, Escayg, French, Fukuda, Gatti, Germano, Hamati-Haddad, Harkin, Haspolat, Heida, Heida, Holtzman, Ichiyama, Isaac, Jiang, Kamal, Kang, Lahat, Le Van Quyen, Lemmens, Morimoto, Morimoto, Moser, Nelson, Pellegrini-Giampietro, Provenzale, Racine, Raspall-Chaure, Richichi, Sanchez, Scantlebury, Schuchmann, Shibasaki, Shinnar, Stafstrom, Takao, Tallie Z. Baram, Tan, Theodore, Toth, Tütüncüoğlu, Verity, Verity, Verity, Vezzani, Virta, Wallace, Zerr   +79 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source