Results 211 to 220 of about 28,282,310 (344)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Interleukin-1 receptor-associated kinase-1 is a therapeutic target for gastric cancer. [PDF]

Discov Oncol
Shi H, Zhang J, Bao X.
europepmc   +1 more source

Targeting Interleukin-1&bgr; Reduces Leukocyte Production After Acute Myocardial Infarction

Circulation, 2015
H. Sager, T. Heidt, M. Hulsmans, Partha Dutta, G. Courties, Matthew Sebas, G. Wojtkiewicz, Benoit Tricot, Y. Iwamoto, Yuan Sun, R. Weissleder, P. Libby, F. Swirski, M. Nahrendorf   +13 more
semanticscholar   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Desmoplakin Cardiomyopathy Presenting With Recurrent Myopericarditis Responsive to Interleukin-1 Blockade. [PDF]

JACC Case Rep
Lopez RI, Marchetta M, Ayers M, Mason P, Thomas M, Gasperetti A, Gilotra NA, Abbate A.   +7 more
europepmc   +1 more source

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America, 1989
W. Sue, T. Griffin, Laura C Stanleyt, Chen Ling, Lanya White, Veronica Macleod, Linda J Perrot, C. White, Iii., C. Araoz   +9 more
semanticscholar   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Tuberculous Meningitis With Paradoxical Reaction in an Immunocompetent Young Male Treated by Interleukin-1 Receptor Antagonist. [PDF]

Case Rep Infect Dis
Kanat A, Toker AK, Özer Şimşek Z, Koç A, Celik I.   +4 more
europepmc   +1 more source

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Myocarditis: An Interleukin-1-Mediated Disease?

Frontiers in Immunology, 2018
Giacomo De Luca, Giulio Cavalli, Giulio Cavalli, Corrado Campochiaro, Moreno Tresoldi, Lorenzo Dagna   +5 more
doaj   +1 more source