Results 221 to 230 of about 24,572,041 (402)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Diagnosis, management, and monitoring of interleukin-1 mediated diseases in Central and Eastern Europe: real-world data. [PDF]

Pediatr Rheumatol Online J
Jelusic M, Sestan M, Toplak N, Tamas C, Vojinovic J, Zuber Z, Wolska-Kusnierz B, Sparchez M, Jesenak M, Rusoniene S, Stanevica V, Dolezalova P, Harel L, Uziel Y, Gattorno M.   +14 more
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice [PDF]

, 1989
R A Pecyk, E B Fraser-Smith, Thomas R. Matthews   +2 more
openalex   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Effective Treatment of Macrophage Activation Syndrome Linked to Systemic Lupus Erythematosus Using Interleukin-1 Inhibitor. [PDF]

Cureus
Barlas N, Kaur IP, Kuzhuppilly Arcilla C, Kaeley GS, Thway M.   +4 more
europepmc   +1 more source

Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta

, 1989
Matthew R. Duncan, Brian D. Berman
openalex   +1 more source

Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5. [PDF]

, 1987
Hajime Hagiwara, Hongyan Huang, Noriyoshi Arai, L A Herzenberg, Ken‐ichi Arai, Albert Zlotnik   +5 more
openalex   +1 more source

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Advanced Science, EarlyView.
MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang   +15 more
wiley   +1 more source

Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development. [PDF]

Front Genet
Huang G, Dong X, Shao X, Wu M, Gao S, Wang Y, Guan X.   +6 more
europepmc   +1 more source