Results 61 to 70 of about 10,723,036 (376)

Interleukin-10 in Human Milk [PDF]

Pediatric Research, 1995
The concentrations of immunoreactive IL-10 in the aqueous fraction of 20 specimens of human milk obtained during the first 80 h of lactation and stored at -60 degrees C ranged from 66 to 9301 pg/mL (mean +/- SD, 3304 +/- 3127 pg/mL). IL-10 was present also in the lipid layer of milk.
R, Garofalo, S, Chheda, F, Mei, K H, Palkowetz, H E, Rudloff, F C, Schmalstieg, D K, Rassin, A S, Goldman   +7 more
openaire   +2 more sources

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice [PDF]

, 2012
Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(
Flavell, Richard A., Fox, James G., Gagliani, Nicola, Hoshi, Namiko, Iwasaki, Akiko, Medzhitov, Ruslan, Nish, Simone A., Reizis, Boris, Schenten, Dominik, Shen, Zeli, Walther, Zenta   +10 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Evaluation of interleukin 8 and interleukin 10 cytokines in liquid based cervical cytology samples

The Pan African Medical Journal, 2019
INTRODUCTION: Inflammatory cytokines have been associated with various cancers, including cervical cancers. Interpreting cytokine expression in liquid based cervical samples is quite challenging.
Daniel David Osiagwu, Alfred Ederialo Azenabor, Abimbola Akinduro Osijirin, Philomina Ikuoyah Awopetu, Folasade Ruth Oyegbami   +4 more
doaj   +1 more source

The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma [PDF]

Jornal Brasileiro de Pneumologia
Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma.
Mariana Isadora Ribeiro Vieira, Mônica Versiani Nunes Pinheiro de Queiroz, Maria Borges Rabelo de Santana, Hatilla dos Santos Silva, Almirane Oliveira, Camila Alexandrina Viana Figueiredo, Eduardo Martín Tarazona Santos, Ryan dos Santos Costa, Laura Maria de Lima Belizário Facury Lasmar   +8 more
doaj   +1 more source

IL-27 Regulated CD4+IL-10+ T Cells in Experimental Sjögren Syndrome

Frontiers in Immunology, 2020
Interleukin 27 (IL-27) plays diverse immune regulatory roles in autoimmune disorders and promotes the generation of IL-10–producing CD4+ T cells characterized by producing the immunosuppressive cytokine IL-10.
Jingjing Qi, Jingjing Qi, Zhuoya Zhang, Xiaojun Tang, Wenchao Li, Weiwei Chen, Genhong Yao   +6 more
doaj   +1 more source

Neuronal synapse formation induced by microglia and interleukin 10. [PDF]

PLoS ONE, 2013
Recently, it was found that microglia regulated synaptic remodeling of the developing brain, but their mechanisms have not been well understood. In this study, the action of microglia on neuronal synapse formation was investigated, and the primary target
So-Hee Lim, Eunha Park, Boram You, Youngseob Jung, A-Reum Park, Sung Goo Park, Jae-Ran Lee   +6 more
doaj   +1 more source

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

medRxiv, 2021
Background: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. Methods: We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform ...
A. Gordon, P. Mouncey, Farah Al-Beidh, K. Rowan, A. Nichol, Y. Arabi, D. Annane, A. Beane, Wilma van Bentum-Puijk, L. Berry, Zahra Bhimani, M. Bonten, C. Bradbury, F. Brunkhorst, Adrian Buzgau, A. Cheng, M. Detry, E. J. Duffy, L. Estcourt, M. Fitzgerald, H. Goossens, R. Haniffa, A. Higgins, T. Hills, Christopher M. Horvat, F. Lamontagne, P. Lawler, H. Leavis, K. Linstrum, E. Litton, E. Lorenzi, J. Marshall, F. Mayr, D. McAuley, A. McGlothlin, S. McGuinness, B. McVerry, S. Montgomery, S. Morpeth, S. Murthy, Katrina Orr, R. Parke, Jane C. Parker, A. Patanwala, V. Pettilä, E. Rademaker, Marlene S. Santos, Christina T. Saunders, C. Seymour, M. Shankar-Hari, W. Sligl, A. Turgeon, Anne M Turner, F. L. van de Veerdonk, R. Zarychanski, Cameron Green, R. Lewis, D. Angus, C. McArthur, S. Berry, S. Webb, L. Derde   +61 more
semanticscholar   +1 more source

Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. [PDF]

, 2008
Different functions have been attributed to natural regulatory CD4+CD25+FOXP+ (Treg) cells during malaria infection. Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites ...
Belanger, B, Cambos, M, Jacques, A, Roulet, A, Scorza, T   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source