Results 41 to 50 of about 79,534,328 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China

Journal of Infection in Developing Countries
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern.
Xiaoyi Liu, Fan Zhang, Jinping Qiao, Wentao He   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Interleukin 10 And 18 levels in Essential Hypertensive

Journal of Applied Sciences and Environmental Management, 2019
The mechanism underlying a sustained blood pressure elevation and its sequelae on the inflammatory cascades have not been totally unraveled. This research was, in addition to body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP ...
O.O. Odewusi, H.B. Osadolor
doaj   +1 more source

Neuroprotective effects of interleukin 10 in spinal cord injury

Frontiers in Molecular Neuroscience, 2023
Spinal cord injury (SCI) starts with a mechanical and/or bio-chemical insult, followed by a secondary phase, leading progressively to severe collapse of the nerve tissue.
Juan Li, Pei Wang, Ting Zhou, Wenwen Jiang, Hang Wu, Shengqi Zhang, Lingxiao Deng, Hongxing Wang   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Progression of periodontal disease and interleukin-10 gene polymorphism

, 2008
Background and Objective: Interleukin-10 is a key immunoregulatory cytokine that may be of significance in the immunopathogenesis of chronic inflammatory diseases such as periodontal disease.
Middleton, P, Palmer, Janet, Taylor, J, Middleton, PG, Hamlet, Stephen, Cullinan, MP, Westerman, Bill, Taylor, JJ, Cullinan, Mary, Westerman, B, Seymour, GJ, Hamlet, SM, Palmer, JE, Faddy, MJ, Faddy, Malcolm, Seymour, G   +15 more
core   +1 more source

Interleukin-10 in Human Milk [PDF]

Pediatric Research, 1995
The concentrations of immunoreactive IL-10 in the aqueous fraction of 20 specimens of human milk obtained during the first 80 h of lactation and stored at -60 degrees C ranged from 66 to 9301 pg/mL (mean +/- SD, 3304 +/- 3127 pg/mL). IL-10 was present also in the lipid layer of milk.
R, Garofalo, S, Chheda, F, Mei, K H, Palkowetz, H E, Rudloff, F C, Schmalstieg, D K, Rassin, A S, Goldman   +7 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat : effects on the inflammatory response [PDF]

, 2007
To determine the effects of inhaled IL-10 at different doses and different time points on the pulmonary and systemic inflammatory response during endotoxemia, 48 ventilated, anaesthetized rats (mean body weight ± standard deviation, 500 ± 33g) were ...
Nguyen, Ngoc-Thach
core