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Leukemia & Lymphoma, 1994
Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors.
S, Kobayashi +3 more
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Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors.
S, Kobayashi +3 more
openaire +4 more sources
The role of proteolysis in interleukin-11 signaling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022Although interleukin-11 (IL-11) was discovered more than 30 years ago, it remains an understudied member of the IL-6 family of cytokines. While it was originally discovered as a secreted factor that could foster megakaryocyte maturation and was therefore used as a recombinant protein to increase platelet production in patients with thrombocytopenia ...
Juliane, Lokau +3 more
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Interleukin‐11: A gp130 Cytokine
Annals of the New York Academy of Sciences, 1998ABSTRACT: Interleukin (IL)‐11 is a member of the gp130 family of cytokines. Comparison of IL‐11 with another gp130 family member, IL‐6, indicates that these two cytokines share many overlapping signal transduction mechanisms. However, unlike IL‐6, treatment of patients with a recombinant human form of IL‐11 (rhIL‐11) does not increase body temperature,
William L, Trepicchio, Andrew J, Dorner
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Measurement of Human Interleukin 11
Current Protocols in Immunology, 1996AbstractThis unit describes an ELISA and a cell proliferation assay that can be used, respectively, to measure the protein level or biologic activity of human and murine interleukin 11 (IL‐11). The bioassay is based on the ability of IL‐11 to support growth of the B9‐11 cell line, a subline of B9 that has traditionally been used to measure levels of IL‐
Frann, Bennett +4 more
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Update on development of interleukin-11
Current Opinion in Hematology, 1995This paper reviews the recent studies of interleukin-11 gene expression and regulation, receptor and signal transduction, pharmacologic effects, and preclinical and clinical studies. Interleukin-11 is expressed in cells of mesenchymal origin and gene expression can be modulated by several inflammatory cytokines and agonists.
X, Du, D A, Williams
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STEM CELLS, 1993
Interleukin (IL)-11 is a bone marrow fibroblast derived cytokine with a wide spectrum of in vitro biological activities in the hematopoietic, lymphopoietic, hepatic, adipose, neuronal and osteoclast systems, either alone or in synergy with other hematopoietic growth factors.
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Interleukin (IL)-11 is a bone marrow fibroblast derived cytokine with a wide spectrum of in vitro biological activities in the hematopoietic, lymphopoietic, hepatic, adipose, neuronal and osteoclast systems, either alone or in synergy with other hematopoietic growth factors.
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Emerging roles for Interleukin-11 in disease
Growth Factors, 2019Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered.
Paul M, Nguyen +2 more
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BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2012
Interleukin-11 (IL-11) is a cytokine which interacts with a variety of haemopoietic and non-haemopoietic cell types. Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.
A J, Dorner, S J, Goldman, J C, Keith
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Interleukin-11 (IL-11) is a cytokine which interacts with a variety of haemopoietic and non-haemopoietic cell types. Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.
A J, Dorner, S J, Goldman, J C, Keith
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Effect of interleukin 11 on normal and pathological thrombopoiesis
Cancer Chemotherapy and Pharmacology, 1996Interleukin 11 (IL-11) is a stromal cell-derived cytokine that has multiple effects on hematopoietic and nonhematopoietic systems. In vitro, it enhances the growth of early progenitors and promotes megakaryocytopoiesis and erythropoiesis. In healthy animals, IL-11 administration stimulates megakaryocyte maturation and increases peripheral platelet ...
M, Teramura +4 more
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