Results 191 to 200 of about 668,836 (354)

A Phase II Study of Docetaxel and Pembrolizumab plus Interleukin 12 Gene Therapy in Nonmetastatic, Anthracycline-Refractory Triple-Negative Breast Cancer (INTEGRAL). [PDF]

Clin Cancer Res
Niravath P, Uzair I, Sun K, Mai H, Guan J, Li M, Deng J, Qian W, Zhou J, Guzman L, Banaglorioso K, Hashmani R, Mathur S, Chang J.   +13 more
europepmc   +1 more source

Inhibition of the Defense System Stimulating Interleukin-12 Interferon-γ Pathway During Critical Illness [PDF]

, 1997
Wolfgang Ertel, Marius Keel, Regula Neidhardt, Ursula Steckholzer, Jean-Pierre Kremer, Udo Ungethuem, O. Trentz   +6 more
openalex   +1 more source

Phenotypic and functional differences of dendritic cells generated under different in vitro conditions [PDF]

, 2003
Ali, SA, Li, G, McArdle, SE, Mian, S, Rees, RC   +4 more
core   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Efficacy of interleukin-12/23 and interleukin-23 inhibitors in Hailey-Hailey disease. [PDF]

JAAD Case Rep
Echeandia-Francis C, Jiang X, Mortlock RD, Goldust M, Milstone LM, Choate KA.   +5 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Osteopontin promoted cardiac inflammation through increased interleukin-12 in acute myocarditis. [PDF]

Mol Biomed
Nie X, Fan J, Qin Y, Wen J, Lu Z, Chen C, Wang DW.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Combined Treatment with Interleukin-12 and Indomethacin Promotes Increased Resistance in BALB/c Mice with EstablishedLeishmania majorInfections

, 2002
Jian Li, Udaikumar M. Padigel, Phillip Scott, Jay P. Farrell   +3 more
openalex   +2 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source