Results 211 to 220 of about 668,836 (354)

Image 1_Evolutionary insights into Interleukin-12 family targets across 405 species.tif

Weibin Wang (1968658), Dawei Li (5704), Kaiyong Luo (21448442), Baozheng Chen (10944447), Xuzhen Li (21448445), Tingting Hao (107457), Dazhong Guo (21448448), Yang Dong (234336), Ya Ning (19855101)   +8 more
openalex   +1 more source

Interleukin-12 inhibits liver-specific drug-inducible systems in vivo [PDF]

, 2008
Hernandez-Alcoceba, R. (Rubén), Kochanek, S. (Stefan), Kramer, M.G. (María Gabriela), Kreppel, F. (Florian), Mauleon, I. (Itsaso), Prieto, J. (Jesús), Reboredo, M. (Mercedes), Rivas, J. (Javier) de las, Zabala, M. (Maider)   +8 more
core  

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Interleukin 12/23 and interleukin 23 inhibitors for moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. [PDF]

Ann Gastroenterol
Sawaf B, Hayek MA, Kassem A, Alsoud D, Alom M, Salam AH, Shembesh RH, Beshr MS, Hallak Y, Abbarh S, Batikh E, Shibani M, Elhadi M, Alastal Y, Regueiro M.   +14 more
europepmc   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Improved Antitumor Activity of Interleukin-12-Secreting Chimeric Antigen Receptor T Cells Targeting CD176 across Different Carcinomas. [PDF]

Transfus Med Hemother
Umland M, Dragon AC, Beermann LM, Bonifacius A, Kehler P, Gellert J, Blasczyk R, Abken H, Schambach A, Hudecek M, Eiz-Vesper B.   +10 more
europepmc   +1 more source

Antitumor Activities of Interleukin-12 in Melanoma. [PDF]

Cancers (Basel), 2022
Gao W, Pan J, Pan J.
europepmc   +1 more source

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

, 1993
Catherine S. Tripp, S F Wolf, Emil R. Unanue   +2 more
openalex   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial. [PDF]

Nat Commun
Park JC, Curti B, Butler M, Wehrenberg-Klee E, Elassal J, Tighe R, Battula S, Iodice G, Kaufman HL, Kirkwood JM.   +9 more
europepmc   +1 more source