Results 221 to 230 of about 6,238,612 (332)

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes.

Blood, 1994
G. Trinchieri
semanticscholar   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities. [PDF]

Protein Sci
Lipinski B, Unmuth L, Arras P, Endruszeit R, Becker S, Rödel JM, Scheller J, Pudewell S, Floss DM, Krah S, Harwardt J, Doerner A, Helming L, Xu C, Menrad A, Evers A, Kolmar H, Elter D, Pekar L, Zielonka S.   +19 more
europepmc   +1 more source

Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency.

Clinical Infectious Diseases, 2014
M. Ouederni, O. Sanal, A. Ikinciogulları, I. Tezcan, F. Doğu, Ithaisa Sologuren, S. Pedraza-Sánchez, M. Keser, G. Tanır, C. Nieuwhof, E. Colino, D. Kumararatne, J. Levy, N. Kutukculer, C. Aytekin, E. Herrera-Ramos, Micah M. Bhatti, N. Karaca, R. Barbouche, A. Broides, E. Goudouris, J. Franco, N. Parvaneh, I. Reisli, A. Strickler, A. Shcherbina, A. Somer, A. Segal, A. Ángel-Moreno, José L Lezana-Fernández, M. Bejaoui, M. Bobadilla-Del Valle, S. Kachboura, T. Sentongo, I. Ben‐Mustapha, J. Bustamante, C. Picard, A. Puel, S. Boisson-Dupuis, L. Abel, J. Casanova, C. Rodríguez-Gallego   +41 more
semanticscholar   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Uncovering the interleukin-12 pharmacokinetic desensitization mechanism and its consequences with mathematical modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
DeBonis J, Veiseh O, Igoshin OA.
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.

Cold Spring Harbor Perspectives in Biology, 2018
Juming Yan, M. Smyth, M. Teng
semanticscholar   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source