Results 81 to 90 of about 6,238,612 (332)
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Cytokine expression in malaria-infected non-human primate placentas [PDF]
, 2012 Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions.
Barasa, M. +8 more
core +4 more sources
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Journal of Experimental Medicine, 1992 Natural killer cell stimulatory factor (NKSF), or interleukin 12 (IL- 12), is a 70-kD heterodimeric cytokine composed of two covalently linked chains, p40 and p35.
A. D’Andrea +19 more
semanticscholar +1 more source
Localized Immunotherapy Delivery Using Injectable in situ Forming Chitosan Hydrogel [PDF]
, 2016 Cytokine-based cancer immunotherapies stimulate a host’s immune system to fight cancer. In particular, interleukin-12 (IL-12), a potent pro-inflammatory cytokine, has demonstrated the ability to eliminate tumors in a number of preclinical models ...
Washispack, Seth
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen +6 more
wiley +1 more source
Interleukin 12: still a promising candidate for tumor immunotherapy?
Cancer Immunology and Immunotherapy, 2014 Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities.
W. Lasek +2 more
semanticscholar +1 more source
Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor β1 deficiency [PDF]
, 2008 postprin
Chan, KW +5 more
core +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source