Results 81 to 90 of about 657,016 (309)

Localized Immunotherapy Delivery Using Injectable in situ Forming Chitosan Hydrogel [PDF]

, 2016
Cytokine-based cancer immunotherapies stimulate a host’s immune system to fight cancer. In particular, interleukin-12 (IL-12), a potent pro-inflammatory cytokine, has demonstrated the ability to eliminate tumors in a number of preclinical models ...
Washispack, Seth
core   +2 more sources

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +5 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Sialidase Deficiency in Porphyromonas gingivalis Increases IL-12 Secretion in Stimulated Macrophages Through Regulation of CR3, IncRNA GAS5 and miR-21

Frontiers in Cellular and Infection Microbiology, 2018
Porphyromonas gingivalis (P. gingivalis) is a major periodontal pathogen that can induce an immune response leading to a destructive inflammatory process.
Xue Yang, Xue Yang, Yaping Pan, Xiaoyu Xu, Xiaoyu Xu, Tong Tong, Shiwen Yu, Yue Zhao, Li Lin, Jingbo Liu, Jingbo Liu, Dongmei Zhang, Dongmei Zhang, Chen Li   +13 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Natural Killer Cell Activity and Interleukin-12 in Metabolically Healthy versus Metabolically Unhealthy Overweight Individuals

Frontiers in Immunology, 2017
The purpose of this study was to determine whether the immune system is involved in the different metabolic circumstances in healthy and unhealthy overweight individuals. We examined the metabolic and immune characteristics of 117 overweight individuals.
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Jong Ho Lee, Jong Ho Lee, Jong Ho Lee   +5 more
doaj   +1 more source

Cytotoxicity and immunomodulatory effects of damnacanthal and nordamnacanthal isolated from roots of morinda elliptica. [PDF]

, 2010
Morinda elliptica has been used traditionally as a medicine to treat various diseases in Malaysia and Southeast Asia. In this present study, the cytotoxicity and immunomodulatory effects of damnacanthal and nordamnacanthal isolated from the roots of ...
Abd Rahman, Mashitoh, Ali, Abdul Manaf, Ho, Yin Wan, Ismail, Nor Hardiani, Lajis, Md Nordin, Mohamed Alitheen, Noorjahan Banu, Mustafa, Shuhaimi, Yeap, Swee Keong   +7 more
core  

Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. [PDF]

, 2005
PURPOSE: To evaluate the feasibility and safety of intratumoral injection of autologous dendritic cells (DCs) transfected with an adenovirus encoding interleukin-12 genes (AFIL-12) for patients with metastatic gastrointestinal carcinomas. Secondarily,
Alfaro, C. (Carlos), Arina, A. (Ainhoa), Bendandi, M. (Maurizio), Benito, A. (Alberto), Feijoo, E. (Esperanza), Herraiz-Bayod, M.J. (Maite J.), Herrero, J.I. (José Ignacio), Lucena, F. (Felipe), Mazzolini, G. (Guillermo), Melero, I. (Ignacio), Olagüe, C. (Cristina), Prieto, J. (Jesús), Qian, C. (Cheng), Quiroga, J. (Jorge), Ruiz, J. (Juan), Sadaba, B. (Belén), Sangro, B. (Bruno), Sola, J. (Josu), Subtil, J.C. (José Carlos), Tirapu, I. (Íñigo)   +19 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Decreased serum level of IL-12 in the course of ischemia and reperfusion during abdominal aortic surgery

Folia Histochemica et Cytobiologica, 2011
Ischemic-reperfusion injury (IRI) is defined as tissue damage, organ dysfunction or failure developed in the course of inflammatory response following ischemia and reperfusion (IR).
Marek Gacko, Andrzej Siemiatkowski, Barbara Mroczko, Monika Jedynak, Maciej Szmitkowski   +4 more
doaj   +1 more source