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Interleukin-13 and Leukotrienes
American Journal of Respiratory Cell and Molecular Biology, 2003The episodic wheezing and shortness of breath caused by events in asthma, have not been extensively investigated. In this issue of the AJRCMB, Vargaftig and Singer address asthma has been recognized since antiquity. As a result, major efforts have been directed at studies of asthma pathothis gap in our knowledge and demonstrate, for the first time ...
Jack A, Elias +4 more
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Journal of Cellular Biochemistry, 2009
AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
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AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
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Immunoregulatory Roles of Interleukin-13 in Cattle
Journal of Interferon & Cytokine Research, 1999Interleukin-13 (IL-13) is produced predominantly by helper T lymphocytes of the Th2 phenotype and mediates its effects on several immune cells, including B lymphocytes and macrophages, stimulating their proliferation, differentiation, and effector functions.
W L, Trigona +3 more
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Interleukin-13: Characterization and biologic properties
1995Upon activation by antigen, helper T cells respond by secreting factors, called cytokines, that coordinate the immune response. The type of T-cell response initiated depends upon the antigenic stimulus and can result in a polarization of the spectrum of cytokines secreted.
A N, McKenzie, G, Zurawski
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1995
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Interleukin-13: Central Mediator of Allergic Asthma
Science, 1998The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in ...
M, Wills-Karp +6 more
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Histopathology, 2001
Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
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Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
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Role of Interleukin-13 in Asthma
Current Allergy and Asthma Reports, 2013Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. Some of the most prominent of the effects of IL-13 include increases in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness, and switching of B cell antibody production from IgM to IgE.
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Interleukin 13 and Related Cytokines
1996The function of CD4-positive, T helper cells is pivotal to the workings of the specific immune system. These cells direct antibody responses to protein antigens and influence cellular immunity by activating macrophages and instigating delayed-type hypersensitivity reactions. T helper cells perform these functions partially through altered expression of
Andrew N. J. McKenzie, Andrew W. Heath
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