Results 251 to 260 of about 5,344,313 (296)
Some of the next articles are maybe not open access.
Transgenic Modeling of Interleukin-13 in the Lung
Chest, 2003Interleukin (IL)-13 is a key cytokine in asthma pathogenesis. We used constitutive and inducible overexpression transgenic mice to characterize the mechanisms by which IL-13 causes phenotypic alterations in the lung. These studies demonstrated that chemokine receptor-2, transforming growth factor-beta(1), and IL-11 play an important role in the ...
Jack A, Elias +7 more
openaire +2 more sources
Role of Interleukin-13 in Asthma
Current Allergy and Asthma Reports, 2013Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. Some of the most prominent of the effects of IL-13 include increases in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness, and switching of B cell antibody production from IgM to IgE.
openaire +2 more sources
Histopathology, 2001
Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
openaire +2 more sources
Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
openaire +2 more sources
Journal of Cellular Biochemistry, 2009
AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
openaire +2 more sources
AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
openaire +2 more sources
Interleukin-13: Characterization and biologic properties
1995Upon activation by antigen, helper T cells respond by secreting factors, called cytokines, that coordinate the immune response. The type of T-cell response initiated depends upon the antigenic stimulus and can result in a polarization of the spectrum of cytokines secreted.
A N, McKenzie, G, Zurawski
openaire +2 more sources
Blood, 2001
Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections
B F, Skinnider +8 more
openaire +3 more sources
Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections
B F, Skinnider +8 more
openaire +3 more sources
Interleukin 13: A Growth Factor in Hodgkin Lymphoma
International Archives of Allergy and Immunology, 2001Classical Hodgkin lymphoma (cHL) is a malignant disorder of lymph nodes with distinctive clinical and pathologic features. These features are thought to be primarily due to the abnormal production of multiple cytokines by the malignant cell population of HL, the Reed-Sternberg (RS) cells.
Skinnider, Brian F. +2 more
openaire +3 more sources
Interleukin 13 and Related Cytokines
1996The function of CD4-positive, T helper cells is pivotal to the workings of the specific immune system. These cells direct antibody responses to protein antigens and influence cellular immunity by activating macrophages and instigating delayed-type hypersensitivity reactions. T helper cells perform these functions partially through altered expression of
Andrew N. J. McKenzie, Andrew W. Heath
openaire +1 more source
Effects of interleukin-13 on human neutrophil functions
Journal of Leukocyte Biology, 1996Abstract It was recently shown that interleukin-13 (IL-13) induces the expression and release of the IL-1 decoy receptor (type II) in human neutrophils along with the production of the IL-1 receptor antagonist. In the present study we focused on further studying the modulatory effects of IL-13 on these cells.
D, Girard +3 more
openaire +2 more sources
The role of interleukin‐13 in infectious diseases and allergy
BioEssays, 2000Cytokines, also referred to as interleukins, are the major orchestrators of host defence processes, and, as such, are involved in insults, repair and restoration of tissue homeostasis. This review summarises recent findings on and emerging models of the biological roles of the double-edged sword interleukin-13 (IL-13), which have been principally ...
openaire +2 more sources