Results 41 to 50 of about 3,159,504 (378)
Frontiers in Endocrinology, 2021 ObjectiveOsteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activator (RANKL) and ...
Hui Zhang +7 more
doaj +1 more source
Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease [PDF]
Immunology, 2010 SummaryInterleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL‐17‐producing cells are generated.
Sarah L. Gaffen +2 more
openaire +3 more sources
BMC Rheumatology, 2020 Background Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with ...
Dovile Sinkeviciute +4 more
doaj +1 more source
Journal of Investigative Surgery, 2021 Background Idiopathic Granulomatous Mastitis (IGM) is a benign chronic inflammatory breast disease that mimics breast cancer, and the etiopathogenesis has not yet been fully evaluated. Autoimmunity has received the most focus as a possible etiology.
Mehmet Saydam +8 more
doaj +1 more source
International Journal of Preventive Medicine, 2019 Background: Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory cytokines which has important role in the inflammation processes can consider as biomchemical markers for early diagnosis and prevention of periimplant ...
Shirin Zahra Farhad +2 more
doaj +1 more source
International Journal of Occupational Medicine and Environmental Health, 2020 Objectives Venom immunotherapy (VIT) is an effective treatment method and is addressed to patients with a history of an anaphylactic reaction to Hymenoptera stings. However, the immunological mechanisms of protection have not been explained yet.
Krzysztof Pałgan +3 more
doaj +1 more source
Interleukin-17 in rheumatoid arthritis: Trials and tribulations
Journal of Experimental Medicine, 2020 IL-17A is a rational therapeutic target in RA; however, clinical trials have shown relatively modest success. This review explores possible reasons for the limited clinical efficacy of IL-17A blockade in RA, guided by recent insights in IL-17 biology.
L. Taams
semanticscholar +1 more source
Interleukin-17 Inhibits Adult Hippocampal Neurogenesis [PDF]
, 2014 Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17
Gan, Yan +7 more
core +3 more sources
The role of interleukin-17 in asthma: a protective response?
ERJ Open Research, 2020 While there now exist effective treatments for type 2 high, eosinophilic asthma, there are no specific therapies for 40–50% of people with asthma with other phenotypes, which result from poorly understood underlying pathological mechanisms.
G. Hynes, T. Hinks
semanticscholar +1 more source
B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]
, 2013 We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall +74 more
core +3 more sources