Results 31 to 40 of about 419,343 (249)

miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

eLife, 2018
Inflammation often induces regeneration to repair the tissue damage. However, chronic inflammation can transform temporary hyperplasia into a fertile ground for tumorigenesis.
Lihua Wang, Ergang Wang, Yi Wang, Robert Mines, Kun Xiang, Zhiguo Sun, Gaiting Zhou, Kai-Yuan Chen, Nikolai Rakhilin, Shanshan Chao, Gaoqi Ye, Zhenzhen Wu, Huiwen Yan, Hong Shen, Jeffrey Everitt, Pengcheng Bu, Xiling Shen   +16 more
doaj   +1 more source

Clinical significance of Interleukin 17 receptor E in diabetic nephropathy

International Immunopharmacology, 2023
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Since there are limited therapeutic options available for the prevention of DN progression, it is imperative to explore novel differentially expressed genes and therapeutic targets for DN.In this study, mice kidney tissue were subjected to transcriptome sequencing and the results ...
Jingjing Wang, Xian Wang, Meixi Wang, Jinni Wang, Yonggui Wu, Xiangming Qi   +5 more
openaire   +2 more sources

MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors [PDF]

Frontiers in Bioscience, 2012
Interleukin-17 cytokines are a family of pro-inflammatory cytokines. Our current studies found: i) IL-17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii)
Jietang, Mai, Anthony, Virtue, Erin, Maley, Tran, Tran, Ying, Yin, Shu, Meng, Meghana, Pansuria, Xiaohua, Jiang, Hong, Wang, Xiao-Feng, Yang   +9 more
openaire   +2 more sources

Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents

Cellular Physiology and Biochemistry, 2017
Background/Aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune ...
Ao-Wang Qiu, Qing-Huai Liu, Jun-Ling Wang   +2 more
doaj   +1 more source

Brodalumab

Turkderm Turkish Archives of Dermatology and Venereology, 2022
Brodalumab is a human monoclonal antibody that inhibits interleukin-17 (IL-17) pathway by binding to IL-17 receptor. In clinical trials, a PASI75 response has been achieved in 82-84% of the patients at week 12.
Murat Borlu
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

Frontiers in Immunology, 2021
Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng, Na Peng, Yuan Tang, Na Yu, Cuicui Wang, Xiaoyan Cai, Lijun Zhang, Dajun Hu, Francesco Ciccia, Liwei Lu   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy [PDF]

Korean Journal of Pediatrics, 2010
Purpose : Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN).
Seung-Ah Baek, Won-Ho Hahn, Byoung-Soo Cho, Sung-Do Kim   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source