Results 21 to 30 of about 419,343 (249)

SELEX-discovered aptamer that inhibits cellular interleukin-17/interleukin-17 receptor interaction and antagonizes interleukin-17 signaling

Bioscience, Biotechnology, and Biochemistry, 2023
ABSTRACT This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with ...
Arifur Rahman Munshi, Tong Wang, Yukio Takamori, Takehiro Ando, Takumi Yokoyama, Daisuke Fuji, Zhehao Xu, Santhana Vedi, Mizuki Yamamoto, Keita Tsukamoto, Takashi Kawakami   +10 more
openaire   +2 more sources

Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer

Science Progress, 2021
The incidence of breast cancer increases annually, and it has become common within families of breast cancer patients. Interleukin-2 activates cytotoxic T lymphocytes, which are important for cancer immunity.
Kenji Gonda, Shoichiro Horita, Yuko Maejima, Seiichi Takenoshita, Kenju Shimomura   +4 more
doaj   +1 more source

Targeting interleukin-17 receptors

Oncotarget, 2015
During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee, Heng-Hsiung, Wu, Chun-Kai, Huang   +2 more
openaire   +2 more sources

The interleukin-17 receptor B subunit is essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. [PDF]

PLoS ONE, 2013
Helicobacter pylori infection leads to an inflammatory response in 100% of infected individuals. The inflammatory cells which are recruited to the gastric mucosa during infection produce several pro- and anti-inflammatory cytokines including several ...
Dennis J Horvath, Jana N Radin, Sung Hoon Cho, M Kay Washington, Holly M Scott Algood   +4 more
doaj   +1 more source

Structural basis of receptor sharing by interleukin 17 cytokines [PDF]

Nature Immunology, 2009
Interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry.
Ely, Lauren K., Fischer, Suzanne, Garcia, K. Christopher   +2 more
openaire   +2 more sources

Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis

Frontiers in Cell and Developmental Biology, 2020
ObjectivesMyeloid dendritic cells (DCs) in patients with allergic rhinitis (AR) express higher levels of IL-17RB, ST2, and TSLPR. However, their functional roles in DCs are much less clear.
Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun, Qintai Yang   +6 more
doaj   +1 more source

Elevated Th17 cell proportion, related cytokines and mRNA expression level in patients with hypertension-mediated organ damage: a case control study

BMC Cardiovascular Disorders, 2022
Background Immune abnormalities and inflammatory responses play critical roles in progression of hypertension. Basic studies have confirmed that Th17 cell and related cytokines are important in promoting hypertension-mediated organ damage, but few ...
Zhuoqun Wang, Jiannan Wang, Pengfei Yang, Xiwen Song, Yongle Li   +4 more
doaj   +1 more source

Gut microbiota of old mice worsens neurological outcome after brain ischemia via increased valeric acid and IL-17 in the blood

Microbiome, 2023
Background Aging is a significant risk factor for ischemic stroke and worsens its outcome. However, the mechanisms for this worsened neurological outcome with aging are not clearly defined.
Xianzhang Zeng, Jun Li, Weiran Shan, Zhongmeng Lai, Zhiyi Zuo   +4 more
doaj   +1 more source

Identification of Crustacean Female Sex Hormone Receptor Involved in Sexual Differentiation of a Hermaphroditic Shrimp

Biomolecules, 2023
The neurohormone crustacean female sex hormone (CFSH) contains a highly conserved interleukin-17 (IL-17) domain in the mature peptide. Although CFSH has been demonstrated to stimulate female sexual differentiation in crustaceans, its receptors (CFSHR ...
Fang Liu, An Liu, Haihui Ye
doaj   +1 more source

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Nature Communications, 2021
Activation of interleukin-17 (IL-17) receptor signaling within intestinal epithelial cells (IECs) promotes colorectal cancer development. Here, the authors show that miR-146a limits inflammation-induced colorectal carcinogenesis by inhibiting both IL-17 ...
Lucien P. Garo, Amrendra K. Ajay, Mai Fujiwara, Galina Gabriely, Radhika Raheja, Chantal Kuhn, Brendan Kenyon, Nathaniel Skillin, Ryoko Kadowaki-Saga, Shrishti Saxena, Gopal Murugaiyan   +10 more
doaj   +1 more source