Results 81 to 90 of about 545,708 (260)

The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes [PDF]

, 2014
Peer reviewedPublisher ...
Berry, Susan, Brookes, Heather, Bryant, Clare E, Drew, Janice, El-Omar, Emad M, Gay, Nick J, Hold, Georgina L, Mayer, Claus, Saunders, Karin A   +8 more
core   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Peripheral inflammation is associated with remote global gene expression changes in the brain [PDF]

, 2014
Background: Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. As a result, patients with
Cavanagh, Jonathan, Graham, Gerard J., McColl, Alison, Thomson, Carolyn A.   +3 more
core   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse [PDF]

, 2017
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized ...
Abbate, A., Buzzetti, Raffaella, Carbone, Salvatore, Lee, P. J. H., Mauro, A. G., Mezzaroma, E., Toldo, S., Van Tassell, B.   +7 more
core   +2 more sources

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

Clinical, Cosmetic and Investigational Dermatology, 2015
Bodo C Melnik Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Germany Abstract: Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet.
Melnik BC
doaj  

Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]

, 2017
Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie, Chen, Renhua, Feng, Weijing, Huang, Hui, Touyz, Rhian M., Wang, Jingfeng, Zhang, Kun, Zhang, Yinyin   +7 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Anti-Inflammatory Effects of Enzymatically Hydrolyzed Pectin from Premna ligustroides Hemsl. Leaves in Gouty Rats Through NLRP3 Inflammasome Inhibition

Polish Journal of Food and Nutrition Sciences
Gout is a rheumatic inflammatory disease resulting from abnormal uric acid metabolism. This study investigated the anti-inflammatory effects and mechanisms of enzymatically hydrolyzed pectin from Premna ligustroides Hemsl.
Liling Deng, Rui He, Heng Yang, Geng Zhong   +3 more
doaj   +1 more source