Results 61 to 70 of about 545,708 (260)

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

Neural Regeneration Research, 2023
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pan   +12 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Subtype‐associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms

The Journal of Pathology: Clinical Research
Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh, Eszter Mezei, Justína Vörös, Katalin Borka, Adrián Pesti, István Kenessey, András Kiss, András Budai   +7 more
doaj   +1 more source

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

Allergology International, 2013
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus.
Susumu Nakae, Hideaki Morita, Tatsukuni Ohno, Ken Arae, Kenji Matsumoto, Hirohisa Saito   +5 more
doaj   +1 more source

Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Cell Reports, 2020
Summary: Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1) infection was used to
Timothy K. Soh, Colin T.R. Davies, Julia Muenzner, Leah M. Hunter, Henry G. Barrow, Viv Connor, Clément R. Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C. Graham, Michael P. Weekes, Colin M. Crump   +12 more
doaj   +1 more source

Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update

Frontiers in Pharmacology, 2021
Neuroinflammatory response is the immune response mechanism of the innate immune system of the central nervous system. Both primary and secondary injury can activate neuroinflammatory response.
Qingying Yu, Tingting Zhao, Molin Liu, Duo Cao, Jiaxin Li, Yanling Li, Mengyao Xia, Xiaoyu Wang, Tingting Zheng, Chuanguo Liu, Xiangyu Mu, Peng Sun   +11 more
doaj   +1 more source

LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]

, 2016
A
Bachert, Claus, Claeys, Cindy, Holtappels, Gabriële, Perez Novo, Claudina, Pezato, Rogerio   +4 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Structural basis of signalling by TIR domain containing proteins [PDF]

Structural Dynamics
The Toll/interleukin-1 receptor (TIR) domain is found in animal, plant and bacterial immune systems, and function through self-association and homotypic interactions with other TIR domains. [1].
Thomas Ve
doaj   +1 more source

Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice

Frontiers in Pharmacology, 2021
Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions.
Hao Liu, Mei-Xian Ou, Qiao-Qiao Han
doaj   +1 more source