Results 41 to 50 of about 346,202 (121)

Structural basis of signalling by TIR domain containing proteins [PDF]

Structural Dynamics
The Toll/interleukin-1 receptor (TIR) domain is found in animal, plant and bacterial immune systems, and function through self-association and homotypic interactions with other TIR domains. [1].
Thomas Ve
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Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

Frontiers in Pharmacology, 2020
In the chronic phase following ischemic stroke, glial scars can prevent axonal regeneration and the intensification of inflammation. The protective effect of inhibition of glycogen synthase kinase-3β (GSK3β) or receptor-interacting protein 1 kinase ...
Jin Liu, Yong-Ming Zhu, Yi Guo, Liang Lin, Zhan-Xiang Wang, Feng Gu, Xin-Yi Dong, Ming Zhou, Yi-Fan Wang, Hui-Ling Zhang   +9 more
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Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

Clinical, Cosmetic and Investigational Dermatology, 2015
Bodo C Melnik Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Germany Abstract: Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet.
Melnik BC
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Anti-Inflammatory Effects of Enzymatically Hydrolyzed Pectin from Premna ligustroides Hemsl. Leaves in Gouty Rats Through NLRP3 Inflammasome Inhibition

Polish Journal of Food and Nutrition Sciences
Gout is a rheumatic inflammatory disease resulting from abnormal uric acid metabolism. This study investigated the anti-inflammatory effects and mechanisms of enzymatically hydrolyzed pectin from Premna ligustroides Hemsl.
Liling Deng, Rui He, Heng Yang, Geng Zhong   +3 more
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Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet

Journal of Inflammation, 2007
Background It was hypothesized that a pro-atherogenic, high saturated fat and cholesterol diet (HCD) would increase the inflammatory response to E. coli endotoxin (LPS) and increase its concentration in plasma after administration to mice.
Stevens Rachel L, Rose Jane L, Liu Tongzheng, Huang Hong, Hoyt Dale G   +4 more
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Multidimensional Predictors of Tirzepatide Efficacy: Clinical, Genetic, and Molecular Biomarkers for Glycemic, Weight, and Organ Protection

Pharmaceuticals
Tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, demonstrates robust efficacy in glycemic control and weight reduction.
Min Hyeok Shin, Jin Woo Jeong, Se Eun Ha, Rajan Singh, Moon Young Lee, Seungil Ro, Tae Yang Yu   +6 more
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4′-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway

Molecules, 2018
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its ...
Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang   +4 more
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Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature

Mediators of Inflammation, 2017
Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose ...
Youde Jiang, Li Liu, Elizabeth Curtiss, Jena J. Steinle   +3 more
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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

Neural Regeneration Research
Postoperative cognitive dysfunction is a severe complication of the central nervous system that occurs after anesthesia and surgery, and has received attention for its high incidence and effect on the quality of life of patients.
Yujia Liu, Xue Han, Yan Su, Yiming Zhou, Minhui Xu, Jiyan Xu, Zhengliang Ma, Xiaoping Gu, Tianjiao Xia   +8 more
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Inflammasomes: a novel potential biomarker for chronic heart failure (review)

Рациональная фармакотерапия в кардиологии
The objective of this review is to analyze publications about biochemical studies of inflammasome profile proteins in patients with heart failure as diagnostic markers and promising therapeutic targets.
Yu. S. Timofeev, V. A. Metelskaya, Sh. M. Rakhmonova, A. L. Borisova, O. N. Dzhioeva, O. M. Drapkina   +5 more
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