Results 31 to 40 of about 128,073,262 (258)

A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]

, 2011
PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core   +3 more sources

Correlation analysis of serum IL1RL1, DAPPER5, and MFGF with poor prognosis in patients with heart failure [PDF]

Journal of Medical Biochemistry
Background: To explore the predictive value of the combined effect of serum Interleukin-1 Receptor-like 1 (IL1RL1), dishevelled-associated protein 5 (DAPPER5), and Metabolic fibroblast growth factor (MFGF) on poor prognosis in patients with heart failure
Yu Cheng, Cao Suyan, Zhang Ying, Zhao Yuyu, Dong Menghao, Liu Yulong   +5 more
doaj   +1 more source

IL-38: A New Player in Inflammatory Autoimmune Disorders

Biomolecules, 2019
Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie, Zhaohao Huang, He Li, Xiuxing Liu, Song Guo Zheng, Wenru Su   +5 more
doaj   +1 more source

Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice

Neural Regeneration Research, 2022
Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results in the inhibition of inflammation, endoplasmic reticulum stress, and reactive oxygen species production and substantial ...
Chang Liu, Yi Cao, Hao-Xiang Wang, Long Zhao, Ya-Xing Chen, Kun-Hong Zhong, Gao-Wei Li, Guo-Qing Wang, Ke-Ru Huang, Ai-Ping Tong, Liang-Xue Zhou   +10 more
doaj   +1 more source

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

Frontiers in Immunology, 2022
NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector ...
Liang Mi, Liang Mi, Xiaobin Min, Xiaobin Min, Yan Chai, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen   +8 more
doaj   +1 more source

Homoplantaginin regulates various pharmacological pathways: Candidate drugs for multi-target relief of cognitive decline and pathological changes in Alzheimer’s disease

Neural Regeneration Research
Alzheimer’s disease is an age-associated neurodegenerative disorder with a complex pathogenesis. As a result, multi-target drug strategies have emerged in the development of anti-Alzheimer’s disease medications.
Li Luo, Tao Yan, Wenna Liu, Ying Gao, Xiuling Tang, Le Yang, Minggao Zhao   +6 more
doaj   +1 more source

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

Frontiers in Pharmacology, 2021
Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou, Zhichao Zhou, Xiaojing Liu, Xiaojing Liu, Hai-Yan Yin, Hai-Yan Yin, Yong Tang, Yong Tang, Xin Cao, Xin Cao   +9 more
doaj   +1 more source

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze, Rad Jafar Soleimani, Mobasheri A., Busch F., Shakibaei M., Busch Franziska, Buhrmann Constanze, Mobasheri Ali, Buhrmann C., Rad J. S., Shakibaei Mehdi, Aldinger C., Aldinger Constance, Montaseri A., Montaseri Azadeh   +27 more
core   +2 more sources

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signalling

, 2022
The Toll/interleukin-1 receptor (TIR) domains are key innate immune signalling modules. Here, we present the crystal structure of the TIR domain of human interleukin-1 receptor 10 (IL-1R10), also called interleukin 1 receptor accessory protein like 2. It
Surekha Nimma, Weixi Gu, Gu, Weixi, Mohammad K. Manik, Nanson, Jeffrey D, Thomas Ve, Bostjan Kobe, Nimma, Surekha, Kobe, Bostjan, Ve, Thomas, Jeffrey D. Nanson, Manik, Mohammad K   +11 more
core   +1 more source