Results 31 to 40 of about 36,224,284 (254)

IL-38: A New Player in Inflammatory Autoimmune Disorders

Biomolecules, 2019
Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie, Zhaohao Huang, He Li, Xiuxing Liu, Song Guo Zheng, Wenru Su   +5 more
doaj   +1 more source

Correlation analysis of serum IL1RL1, DAPPER5, and MFGF with poor prognosis in patients with heart failure [PDF]

Journal of Medical Biochemistry
Background: To explore the predictive value of the combined effect of serum Interleukin-1 Receptor-like 1 (IL1RL1), dishevelled-associated protein 5 (DAPPER5), and Metabolic fibroblast growth factor (MFGF) on poor prognosis in patients with heart failure
Yu Cheng, Cao Suyan, Zhang Ying, Zhao Yuyu, Dong Menghao, Liu Yulong   +5 more
doaj   +1 more source

Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice

Neural Regeneration Research, 2022
Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results in the inhibition of inflammation, endoplasmic reticulum stress, and reactive oxygen species production and substantial ...
Chang Liu, Yi Cao, Hao-Xiang Wang, Long Zhao, Ya-Xing Chen, Kun-Hong Zhong, Gao-Wei Li, Guo-Qing Wang, Ke-Ru Huang, Ai-Ping Tong, Liang-Xue Zhou   +10 more
doaj   +1 more source

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes:the MRC-ILA Heart Study [PDF]

, 2014
AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation.
Greenwood, J.P., Hall, Alistair S., Rothman, A.M.K., Morton, Allison C., Foley, C., Chase, A., Greenwood, John P, Chase, Alex, Morton, Allison C, Wang, Duolao, Rothman, Alexander M K, Banya, Winston, Clarke, B., Gunn, J., Crossman, David C, Rothman, Alexander M. K., Crossman, David C., Flather, Marcus D, Rothman, Alexander M.K., Clarke, Bernard, Fox, Keith, Fox, K., Banya, W., Hall, Alistair S, Gunn, Julian, Flather, Marcus D., Greenwood, John P., Foley, Claire, Hall, A.S., Morton, A.C.   +29 more
core   +1 more source

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

Frontiers in Immunology, 2022
NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector ...
Liang Mi, Liang Mi, Xiaobin Min, Xiaobin Min, Yan Chai, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen   +8 more
doaj   +1 more source

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

Frontiers in Pharmacology, 2021
Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou, Zhichao Zhou, Xiaojing Liu, Xiaojing Liu, Hai-Yan Yin, Hai-Yan Yin, Yong Tang, Yong Tang, Xin Cao, Xin Cao   +9 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate

Frontiers in Molecular Neuroscience, 2017
The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration.
Seoung Youn Won, Cha Yeon Kim, Doyoun Kim, Jaewon Ko, Ji Won Um, Sung Bae Lee, Matthias Buck, Eunjoon Kim, Eunjoon Kim, Won Do Heo, Won Do Heo, Jie-Oh Lee, Ho Min Kim, Ho Min Kim   +13 more
doaj   +1 more source

Atorvastatin suppresses lipopolysaccharide-induced inflammation in human coronary artery endothelial cells

Brazilian Journal of Pharmaceutical Sciences, 2022
The present study was designed to examine the effects of atorvastatin on vascular inflammatory responses in human coronary artery endothelial cells(HCAECs), when challenged by lipopolysaccharide (LPS), a Toll-like receptor-4 (TLR4) ligand.
Zhen Tian, Zhitao Li, Tian Guo, He Li, Yanshuang Mu   +4 more
doaj   +1 more source