Results 31 to 40 of about 346,202 (121)

Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

PLoS ONE, 2014
Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-
Isabel Fernández-Pisonero, Javier López, Esther Onecha, Ana I Dueñas, Patricia Maeso, Mariano Sánchez Crespo, José Alberto San Román, Carmen García-Rodríguez   +7 more
doaj   +1 more source

Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration

Journal of Dairy Science
: The aim of this study was to evaluate transcriptional changes in the sole epidermis and dermis of bovine claws with septic sole ulceration of the lateral claw.
T.L. Reeder, D.S. Zarlenga, A.L. Ziegler, R.M. Dyer   +3 more
doaj   +1 more source

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo

Food Chemistry: X, 2022
The chemical structure of GLP-1, a novel water-soluble heteropolysaccharide purified Ganoderma leucocontextum fruiting bodies, has been characterized in our previous study.
Xiong Gao, Ranhua Zeng, Jiayi Qi, Chi-Tang Ho, Bin Li, Zhongzheng Chen, Shaodan Chen, Chun Xiao, Huiping Hu, Manjun Cai, Yizhen Xie, Qingping Wu   +11 more
doaj   +1 more source

Structural Mechanism of Receptor-Triggered MyD88 Oligomeric Assembly in Innate Immune Signaling

Nature Communications
MyD88 plays a pivotal role in Toll-like receptor (TLR) and interleukin-1 family signaling through its oligomerization upon receptor activation, leading to downstream protein recruitment.
Kazuki Kasai, Kayo Imamura, Masatoshi Uno, Shiho Nukui, Naotaka Sekiyama, Tomoko Miyata, Fumiaki Makino, Ryusei Yamada, Yoshiki Takahashi, Noriyuki Kodera, Keiichi Namba, Hidenori Ohnishi, Akihiro Narita, Hiroki Konno, Hidehito Tochio   +14 more
doaj   +1 more source

The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease

Journal of Neuroinflammation, 2023
Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered a potential susceptibility gene for Parkinson’s disease (PD), and has been demonstrated to possess protective effects against inflammation-induced neuronal damage.
Tianbai Li, Xiang Tan, Lulu Tian, Congcong Jia, Cheng Cheng, Xi Chen, Min Wei, Yuanyuan Wang, Yiying Hu, Qiqi Jia, Yang Ni, Murad Al-Nusaif, Song Li, Weidong Le   +13 more
doaj   +1 more source

Subtype‐associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms

The Journal of Pathology: Clinical Research
Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh, Eszter Mezei, Justína Vörös, Katalin Borka, Adrián Pesti, István Kenessey, András Kiss, András Budai   +7 more
doaj   +1 more source

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

Neural Regeneration Research, 2023
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pan   +12 more
doaj   +1 more source

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

Allergology International, 2013
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus.
Susumu Nakae, Hideaki Morita, Tatsukuni Ohno, Ken Arae, Kenji Matsumoto, Hirohisa Saito   +5 more
doaj   +1 more source

Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Cell Reports, 2020
Summary: Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1) infection was used to
Timothy K. Soh, Colin T.R. Davies, Julia Muenzner, Leah M. Hunter, Henry G. Barrow, Viv Connor, Clément R. Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C. Graham, Michael P. Weekes, Colin M. Crump   +12 more
doaj   +1 more source

Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats

Brain Research Bulletin
Background: Depression is associated with lowered mood, anxiety, anhedonia, cognitive impairments, and even suicidal tendencies in severe cases. Yet few studies have directed acupuncture's mechanism toward enhancing axonal repair correlated with synaptic
Tao Tong, Chongyao Hao, Junliang Shen, Siyu Liu, Simin Yan, Muhammad Shahzad Aslam, Yiping Chen, Wenjie Chen, Jianguo Li, Yuhan Li, Jingyu Zeng, Meng Li, Zhuoran You, Tuergong Gulizhaerkezi, Simiao Wei, Anning Zhu, Xianjun Meng   +16 more
doaj   +1 more source