Results 11 to 20 of about 128,073,262 (258)

The binding and activation of the glucagon-like peptide-1 receptor by exendin-4 [PDF]

, 2010
Background and purpose Exendin-4 (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus.
Nasr, Elsayed Mohammed Nasr
core   +5 more sources

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]

, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson, Sofat, N, Nidhi Sofat, Wait, R, Robertson, SD, Robin Wait   +5 more
core   +1 more source

Toll/interleukin-1 receptor domains in bacterial and plant immunity

, 2023
The Toll/interleukin-1 receptor (TIR) domain is found in animal, plant, and bacterial immune systems. It was first described as a protein-protein interaction module mediating signalling downstream of the Toll-like receptor and interleukin-1 receptor ...
Bostjan Kobe, Thomas Ve, Mohammad K Manik, Kobe, Bostjan, Shi, Yun, Yun Shi, Li, Sulin, Ve, Thomas, Sulin Li, Manik, Mohammad K   +9 more
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Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages [PDF]

, 2002
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J, Foo Y. Liew, Sester, David P, Katryn J. Stacey, Xu, Damo, David P. Sester, Rebecca C. McDonald, David A. Hume, McDonald, Rebecca C, Campbell, Carol C, Stacey, Katryn J, Hume, David A, Liew, Foo Y, Matthew J. Sweet, Carol C. Campbell, Damo Xu   +15 more
core   +1 more source

Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

Inflammation and Regeneration, 2017
The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial role in interleukin-1 maturation or specific ...
Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata, Junya Masumoto   +8 more
doaj   +1 more source

Identification and function of myeloid differentiation factor 88 (MyD88) in Litopenaeus vannamei. [PDF]

PLoS ONE, 2012
Myeloid differentiation factor 88 (MyD88) is a universal and essential signaling protein in Toll-like receptor/interleukin-1 receptor-induced activation of nuclear factor-kappa B.
Shuang Zhang, Chao-Zheng Li, Hui Yan, Wei Qiu, Yong-Gui Chen, Pei-Hui Wang, Shao-Ping Weng, Jian-Guo He   +7 more
doaj   +1 more source

Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteriod insensitive 1 receptor oligomerization [PDF]

, 2008
Receptor kinases play a key role in the cellular perception of signals. To verify models for receptor activation through dimerization, an experimental system is required to determine the precise oligomerization status of proteins within living cells ...
Vries, S.C., de, Russinova, Eugenia, Shah, K., Vries, S.C., de Vries, Sacco C, Hink, M.A., Shah, Khalid, Hink, Mark A, Visser, A.J.W.G., Russinova, E.T., Visser, Antonie JWG, Russinova, E.   +11 more
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Suppression of interleukin-1 beta and LDL scavenger receptor expression in macrophages by a selective protein kinase C inhibitor.

Journal of Lipid Research, 1991
A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (
AL Akeson, K Schroeder, C Woods, CJ Schmidt, W D Jones   +4 more
doaj   +1 more source

Regulation by Nrf2 of IL-1β-induced inflammatory and oxidative response in VSMC and its relationship with TLR4

Frontiers in Pharmacology, 2023
Introduction: Vascular oxidative stress and inflammation play an important role in the pathogenesis of cardiovascular diseases (CVDs). The proinflammatory cytokine Interleukin-1β (IL-1β) participates in the vascular inflammatory and oxidative responses ...
Zoe González-Carnicero, Raquel Hernanz, Raquel Hernanz, Marta Martínez-Casales, María Teresa Barrús, Ángela Martín, Ángela Martín, María Jesús Alonso, María Jesús Alonso   +8 more
doaj   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Kasukawa, T, Himes, S Roy, Kawai, Jun, Waddell, Nic, Hayashizaki, Yoshihide, Kasukawa, Takeya, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +35 more
core   +1 more source