Results 21 to 30 of about 346,202 (121)

CCPG1 involved in corneal Aspergillus fumigatus infection [PDF]

open access: yesInternational Journal of Ophthalmology, 2022
AIM: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1 (CCPG1) is involved in the corneal antifungal immune response.
Li-Mei Wang   +8 more
doaj   +1 more source

Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice

open access: yesNeural Regeneration Research, 2022
Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results in the inhibition of inflammation, endoplasmic reticulum stress, and reactive oxygen species production and substantial ...
Chang Liu   +10 more
doaj   +1 more source

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

open access: yesFrontiers in Immunology, 2022
NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector ...
Liang Mi   +8 more
doaj   +1 more source

IL-38: A New Player in Inflammatory Autoimmune Disorders

open access: yesBiomolecules, 2019
Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie   +5 more
doaj   +1 more source

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

open access: yesFrontiers in Pharmacology, 2021
Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou   +9 more
doaj   +1 more source

Atorvastatin suppresses lipopolysaccharide-induced inflammation in human coronary artery endothelial cells

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2022
The present study was designed to examine the effects of atorvastatin on vascular inflammatory responses in human coronary artery endothelial cells(HCAECs), when challenged by lipopolysaccharide (LPS), a Toll-like receptor-4 (TLR4) ligand.
Zhen Tian   +4 more
doaj   +1 more source

LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate

open access: yesFrontiers in Molecular Neuroscience, 2017
The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration.
Seoung Youn Won   +13 more
doaj   +1 more source

N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways

open access: yesActa Biochimica et Biophysica Sinica, 2022
Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases. However, there is a lack of effective drugs to treat neuroinflammation.
Huang Lijun   +12 more
doaj   +1 more source

Antimicrobial Peptide Epinecidin-1 Modulates MyD88 Protein Levels via the Proteasome Degradation Pathway

open access: yesMarine Drugs, 2017
The cationic antimicrobial peptide epinecidin-1 was identified from Epinephelus coioides and possesses multiple biological functions, including antibacterial, antifungal, anti-tumor, and immunomodulatory effects.
Bor-Chyuan Su, Jyh-Yih Chen
doaj   +1 more source

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

open access: yesFrontiers in Cellular and Infection Microbiology
Virus infection is one of the greatest threats to human life and health. In response to viral infection, the host’s innate immune system triggers an antiviral immune response mostly mediated by inflammatory processes.
Zhaoyang Yue   +18 more
doaj   +1 more source

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