Results 1 to 10 of about 161,071 (201)

Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas [PDF]

Heliyon, 2023
Inflammation, especially chronic inflammation, is closely linked to tumor development. As essential chronic inflammatory cytokines, the interleukin family plays a key role in inflammatory infections and malignancies.
Yujie Ding, Jie Yi, Jinxin Wang, Zhida Sun   +3 more
doaj   +2 more sources

Apolipoprotein B and interleukin 1 receptor antagonist: reversing the risk of coronary heart disease [PDF]

Frontiers in Endocrinology, 2023
AimsEpidemiological evidence for the link of interleukin 1 (IL-1) and its inhibition with cardiovascular diseases (CVDs) remains controversial. We aim to investigate the cardiovascular effects of IL-1 receptor antagonist (IL-1Ra) and underlying ...
Fangkun Yang, Fangkun Yang, Fangkun Yang, Ning Huangfu, Ning Huangfu, Ning Huangfu, Jiaxi Shen, Jiaxi Shen, Pengpeng Su, Lujie Zhu, Lujie Zhu, Hanbin Cui, Hanbin Cui, Hanbin Cui, Shuai Yuan   +14 more
doaj   +2 more sources

Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis [PDF]

Scientific Reports, 2022
Interleukin (IL) 1, and its family member, IL-1 receptor antagonist (IL-1ra), are involved in the pathogenesis and inflammation perpetuation of patients with rheumatoid arthritis (RA).
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra Gonzalez-Delgado, Miguel Ángel González-Gay, Iván Ferraz-Amaro   +6 more
doaj   +2 more sources

Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist [PDF]

Communications Biology
Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear.
Paula O. Cooper, Jiang Yang, Hsing-Hui Wang, Meaghan M. Broman, Shyaman Madhawa Jayasundara, Subhransu Sekhar Sahoo, Bingyu Yan, Gada D. Awdalkreem, Gregory M. Cresswell, Liang Wang, Emery Goossens, Nadia A. Lanman, Rebecca W. Doerge, Faye Zheng, Liang Cheng, Saeed Alqahtani, Scott A. Crist, Robert E. Braun, Majid Kazemian, Travis J. Jerde, Timothy L. Ratliff   +20 more
doaj   +2 more sources

Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression [PDF]

Biomedicines, 2020
Background: Inflammation is known to promote tumor formation and progression; however, we found a natural anti-inflammatory factor, interleukin (IL)-1 receptor antagonist (IL1RN), in a mouse transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1 ...
Yu-Ching Fan, Kuan-Der Lee, Yuan-Chin Tsai   +2 more
doaj   +2 more sources

Therapeutic role of interleukin-1 receptor antagonist in pancreatic diseases: mendelian randomization study [PDF]

Frontiers in Immunology, 2023
BackgroundThe interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic pancreatitis and ...
Shuai Yuan, Yuyang Miao, Yuyang Miao, Xixian Ruan, Jie Chen, Xue Li, Susanna C. Larsson, Susanna C. Larsson   +7 more
doaj   +2 more sources

Partial response to anakinra in life-threatening Henoch-Schönlein purpura: case report [PDF]

Pediatric Rheumatology Online Journal, 2011
Henoch-Schönlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening ...
Boyer Erynn M, Turman Martin, O'Neil Kathleen M   +2 more
doaj   +3 more sources

Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist [PDF]

JAAD Case Reports
Nathan Mooney, MMSc, Arshpreet Grewal, BS, Susan Pei, MD, Paul Bogner, MD, Drew Kuraitis, MD, PhD   +4 more
doaj   +2 more sources

Interleukin expression after injury and the effects of interleukin-1 receptor antagonist. [PDF]

PLoS ONE, 2013
Ligament healing follows a series of complex coordinated events involving various cell types, cytokines, as well as other factors, producing a mechanically inferior tissue more scar-like than native tissue.
Connie S Chamberlain, Ellen M Leiferman, Kayt E Frisch, Stacey L Brickson, William L Murphy, Geoffrey S Baer, Ray Vanderby   +6 more
doaj   +1 more source

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source