Results 171 to 180 of about 26,112,494 (338)

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

Science Translational Medicine, 2013
K. Matsuoka, J. Koreth, Haesook T. Kim, Gregory Bascug, Sean M McDonough, Y. Kawano, K. Murase, C. Cutler, V. Ho, E. Alyea, P. Armand, B. Blazar, J. Antin, R. Soiffer, J. Ritz   +14 more
semanticscholar   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Preoperative inflammatory profile in chronic coronary syndrome reveals interleukin-2 as a promising biomarker for postoperative atrial fibrillation risk stratification. [PDF]

Int J Cardiol Heart Vasc
Cozac DA, Somkereki C, Nicoara TR, Huțanu A, Demian L, Cabac-Pogorevici I, Scridon A.   +6 more
europepmc   +1 more source

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

Blood, 2014
Frédéric Van Gool, Ari B. Molofsky, Malika M. Morar, M. Rosenzwajg, Hong-Erh Liang, D. Klatzmann, R. Locksley, J. Bluestone   +7 more
semanticscholar   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

The Predictive Significance of Interleukin-2 Receptor in Patients with Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Tian Z, Guo Y, Yang R, Yang W.
europepmc   +1 more source

Quadruple-drug induction therapy in highly sensitized patients [PDF]

, 1988
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Schleibner, S.   +3 more
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

The predictive value of interleukin-2 receptor and prognostic nutritional index in patients with diffuse large B-cell lymphoma. [PDF]

Front Med (Lausanne)
Xie F, Li Y, Zhu X, Zhu J, Ma X, Yan D, Liang A, Xiu B.   +7 more
europepmc   +1 more source

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.

Immunity, 1995
D. Willerford, Jianzhu Chen, J. Ferry, L. Davidson, A. Ma, A. Ma, Frederick W. Alt, Frederick W. Alt   +7 more
semanticscholar   +1 more source