Results 181 to 190 of about 26,112,494 (338)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Efficacy and safety of low-dose interleukin 2 for Behçet's syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial. [PDF]

Nat Commun
Liu T, Zhou W, Zhu Y, Xia W, Chen J, Xiao X, Huang B, Feng R, Ye H, Chen S, Zhang X, Shao M, Li C, Jia Y, Miao M, Jin Y, Li X, Zhang X, Zhou Y, Li R, Zhang X, Su Y, Liu H, Li J, Hu F, Guo J, Sun X, He J, Li Z.   +28 more
europepmc   +1 more source

Monoclonal antibodies against the Crohn´s disease - involved pancreatic autoantigen [PDF]

, 1988
Horbach, E., Otte, M., Poschmann, A., Schwarting, K., Scriba, Peter Christian, Stöcker, W.   +5 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Interleukin-2 Surface Displayed M1 Macrophage-Derived Extracellular Vesicles for Modulating the Tumor Microenvironment. [PDF]

Int J Nanomedicine
Kim KT, Lee JH, Kang SJ, Rhee WJ.
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Combined administration of interleukin-2 and 18 with anti-PD-L1 antibody induces CCL5-positive CD8 T cells to suppress liver tumors. [PDF]

PNAS Nexus
Kimura M, Yamaji K, Harada K, Kawaji H, Imamura J, Okamura H, Tanaka Y, Kohara M, Kimura K.   +8 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Serum level of soluble Interleukin-2 receptor among human papilloma virus infected female patients. [PDF]

Infect Agent Cancer
Yasin MM, Hassan RA, El Sayed AA, Ezzelarab SS, Helal MM, Abdelhady AS.   +5 more
europepmc   +1 more source

gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.

New England Journal of Medicine, 2011
D. Schwartzentruber, D. Lawson, J. Richards, R. Conry, Donald M Miller, J. Treisman, F. Gailani, L. Riley, K. Conlon, B. Pockaj, K. Kendra, R. White, Rene C. Gonzalez, T. Kuzel, B. Curti, P. D. Leming, E. Whitman, J. Balkissoon, D. Reintgen, H. Kaufman, F. Marincola, M. Merino, S. Rosenberg, P. Choyke, D. Vena, P. Hwu   +25 more
semanticscholar   +1 more source