Results 211 to 220 of about 26,112,494 (338)

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Regulatory function of HSA-miR-186-5p on interleukin-2 expression in lumbar degenerative disc disease: a case-control study and subgroups analysis. [PDF]

Neurosurg Rev
Yaltırık CK, Öndüç GG, Álvarez Noval MK, Etli MU, Sarıkaya C, Bakirezer SD, Yilmaz SG, Şerifoğlu L, Özdoğan S.   +8 more
europepmc   +1 more source

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

Nature, 2006
Matthew A. Williams, A. Tyznik, M. Bevan
semanticscholar   +1 more source

Synthetic virus-like gene delivery systems [PDF]

, 1994
Birnstiel, Max L., Buschle, M., Cotten, Matt, Guy, Richard H., Plank, Christian, Wagner, Ernst, Zauner, W.   +6 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Synergistic effects of oral inoculation with recombinant Lactobacillus plantarum NC8 Co-expressing interleukin-2, interleukin-17b and interleukin-26 on infectious bronchitis vaccination in chickens. [PDF]

Poult Sci
Peng J, Guo S, Liu Y, Hao W, Yang X, Zhu S, Gao R.   +6 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect. [PDF]

Front Immunol
Caballero Aguirrechu I, Mestre Fernández B, Soriano García JL, Lim Alonso N, Soto García A, Fleites Calvo V, Mariño de la Puente D, Vega Carvajal G, Ávila Pérez JC, Mendoza Hernández I, García López E, Tarinas Reyes A, García-Pérez G, Díaz Borges C, Ledón Naranjo N, Lozada Chang SL, García Vega Y, Alvárez Lobaina A, Alvárez Cardona M, Lorenzo-Luaces Alvárez P, Crombet Ramos T, Carmenate Portilla T, León Monzón K.   +22 more
europepmc   +1 more source

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.

Immunity, 2010
M. Pipkin, J. Sacks, Fernando Cruz-Guilloty, M. Lichtenheld, M. Bevan, A. Rao   +5 more
semanticscholar   +1 more source